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Female BALB\/c mice were immunized three times with 2.5\u00a0\u00d7\u00a010<jats:sup>11<\/jats:sup>phage particles without adjuvant. Animals vaccinated with phage clones produced high titres of anti-mimotope antibodies and a significant reduction in fluke burden was observed following challenge with metacercariae of<jats:italic>F. hepatica<\/jats:italic>. The proteolytic activity in hepatic tissue was reduced after the immunization with phage clones.<\/jats:p>","DOI":"10.1017\/s0022149x1000026x","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T10:02:51Z","timestamp":1272276171000},"page":"51-55","source":"Crossref","is-referenced-by-count":11,"title":["Proteolytic activity in<i>Fasciola hepatica<\/i>is reduced by the administration of cathepsin L 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