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Helminthol."],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ethanolic and aqueous extracts of selected medicinal plants from Cameroon and Ghana were assessed for their <jats:italic>in vitro<\/jats:italic> anthelmintic activity by using the bovine filarial parasite <jats:italic>Onchocerca ochengi<\/jats:italic> and the free living nematode <jats:italic>Caenorhabditis elegans<\/jats:italic>, a model organism for research on nematode parasites. Worms were incubated in the presence of different concentrations of extracts and inhibitory effects were monitored at different time points. Among the extracts used in this study, ethanolic extracts of <jats:italic>Anogeissus leiocarpus<\/jats:italic>, <jats:italic>Khaya senegalensis<\/jats:italic>, <jats:italic>Euphorbia hirta<\/jats:italic> and aqueous extracts from <jats:italic>Annona senegalensis<\/jats:italic> and <jats:italic>Parquetina nigrescens<\/jats:italic> affected the growth and survival of <jats:italic>C. elegans<\/jats:italic> and <jats:italic>O. ochengi<\/jats:italic> significantly. The mortality was concentration dependent with an LC<jats:sub>50<\/jats:sub> ranging between 0.38 and 4.00\u00a0mg\/ml for <jats:italic>C. elegans<\/jats:italic> (after 72\u00a0h) and between 0.08 and 0.55\u00a0mg\/ml for <jats:italic>O. ochengi<\/jats:italic> after a 24\u00a0h incubation time. Preliminary phytochemical screenings on these extracts revealed the presence of flavonoids, alkaloids, saponins, carbohydrates and tannins in the extracts. Accordingly, application of <jats:italic>A. leiocarpus<\/jats:italic>, <jats:italic>K. senegalensis<\/jats:italic>, <jats:italic>E. hirta<\/jats:italic> and <jats:italic>A. senegalensis<\/jats:italic> extracts could provide alternatives in the control of helminthic infections.<\/jats:p>","DOI":"10.1017\/s0022149x10000635","type":"journal-article","created":{"date-parts":[[2010,9,24]],"date-time":"2010-09-24T10:56:19Z","timestamp":1285325779000},"page":"304-312","source":"Crossref","is-referenced-by-count":53,"title":["<i>In vitro<\/i> activity of Cameroonian and Ghanaian medicinal plants on parasitic (<i>Onchocerca ochengi<\/i>) and free-living (<i>Caenorhabditis elegans<\/i>) 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