{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T04:40:05Z","timestamp":1686112805488},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T00:00:00Z","timestamp":1306800000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previously, an<jats:italic>in vitro<\/jats:italic>effect was observed on the complement system not only of the excretory-secretory products but also of somatic antigens from L3<jats:italic>Anisakis simplex<\/jats:italic>larvae. In the present work the effect of anti-<jats:italic>A. simplex<\/jats:italic>specific antibodies on C3 and C4 levels in human sera was investigated. Up to 309 samples of sera were tested to determine levels of C3 and C4 and anti-<jats:italic>A. simplex<\/jats:italic>antibodies, including immunoglobulins IgG, IgM, IgA and IgE. Significant differences were observed between levels of C3 and C4 and all immunoglobulins except for IgE. In the case of immunoglobulins, the probability that an anti-<jats:italic>A. simplex<\/jats:italic>positive subject has a C3 deficiency was 3.8 times higher than a subject without specific antibodies. In conclusion, an association between elevated levels of anti-<jats:italic>A. simplex<\/jats:italic>antibodies and C3 and C4 deficiency was demonstrated.<\/jats:p>","DOI":"10.1017\/s0022149x11000241","type":"journal-article","created":{"date-parts":[[2011,5,31]],"date-time":"2011-05-31T13:05:32Z","timestamp":1306847132000},"page":"197-201","source":"Crossref","is-referenced-by-count":2,"title":["The effect of anti-<i>Anisakis simplex<\/i>antibody levels on C3 and C4 complement components in human 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