{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:37:47Z","timestamp":1761647867377},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T00:00:00Z","timestamp":1307491200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A longitudinal study was conducted to evaluate the impact of praziquantel (PZQ) for the treatment of <jats:italic>Schistosoma mansoni<\/jats:italic> infection among schoolchildren in Al Gunaid in Central Sudan. A cohort of schoolchildren (6\u201315 years of age) was investigated before and 1 year after treatment with a single dose of PZQ 40\u00a0mg\/kg. Parasitological examinations for <jats:italic>S. mansoni<\/jats:italic> were performed before and after treatment, and prevalence and intensity of infection were analysed. Of 2741 schoolchildren recruited from six elementary schools at baseline, 2521 were successfully traced and re-examined at follow-up, with two complete sets of longitudinal parasitological data on <jats:italic>S. mansoni<\/jats:italic>. Boys showed significantly higher prevalence of <jats:italic>S. mansoni<\/jats:italic> infection than girls. A single dose of PZQ reduced the overall prevalence of <jats:italic>S. mansoni<\/jats:italic> infection by 36.7% (from 59.1 to 37.4%) and the intensity of infection by 41.1% (from 116.7 to 68.7 eggs per gram of stool) 1 year after treatment. The reduction in prevalence was significantly higher among the group of children with heavy infections (by 76.1%, from 6.7 to 1.6%) and among girls (by 54.1%, 42.3 to 19.4%) at 1 year after treatment. Thus, in spite of a significant reduction in the prevalence and intensity of <jats:italic>S. mansoni<\/jats:italic> infection 1 year after PZQ treatment, the prevalence of the disease was still high and further research is needed on this topic.<\/jats:p>","DOI":"10.1017\/s0022149x11000290","type":"journal-article","created":{"date-parts":[[2011,6,8]],"date-time":"2011-06-08T09:37:16Z","timestamp":1307525836000},"page":"228-232","source":"Crossref","is-referenced-by-count":21,"title":["High levels of <i>Schistosoma mansoni<\/i> infections among schoolchildren in central Sudan one year after treatment with praziquantel"],"prefix":"10.1017","volume":"86","author":[{"given":"A.M.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.A.","family":"El Tash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.Y.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Adam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,6,8]]},"reference":[{"key":"S0022149X11000290_ref21","volume-title":"Prevention and control of schistosomiasis and soil-transmitted helminthiasis","year":"2002"},{"key":"S0022149X11000290_ref20","volume-title":"Report of the WHO informal consultation on schistosomiasis control","year":"1999"},{"key":"S0022149X11000290_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(03)00029-9"},{"key":"S0022149X11000290_ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2001.00811.x"},{"key":"S0022149X11000290_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(03)00036-1"},{"key":"S0022149X11000290_ref22","volume-title":"Preventive chemotherapy in human helminthiasis","year":"2006"},{"key":"S0022149X11000290_ref14","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1995.53.167"},{"key":"S0022149X11000290_ref12","volume-title":"Guidelines for the evaluation of soil-transmitted helminthiasis and schistosomiasis at community level","author":"Montresor","year":"1998"},{"key":"S0022149X11000290_ref19","volume-title":"The control of schistosomiasis","year":"1993"},{"key":"S0022149X11000290_ref6","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.214"},{"key":"S0022149X11000290_ref23","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-5-27"},{"key":"S0022149X11000290_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X09990368"},{"key":"S0022149X11000290_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(06)70521-7"},{"key":"S0022149X11000290_ref1","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1996.11813041"},{"key":"S0022149X11000290_ref15","first-page":"703","article-title":"A simple thick smear technique for diagnosis of S. mansoni","volume":"54","author":"Teesdale","year":"1976","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X11000290_ref2","doi-asserted-by":"publisher","DOI":"10.1179\/000349809X12502035776234"},{"key":"S0022149X11000290_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(00)00122-4"},{"key":"S0022149X11000290_ref7","first-page":"87","volume-title":"Human schistosomiasis","author":"Jordan","year":"1993"},{"key":"S0022149X11000290_ref8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2471\/BLT.06.030353","article-title":"Impact of a national helminth control programme on infection and morbidity in Ugandan schoolchildren","volume":"85","author":"Kabatereine","year":"2007","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X11000290_ref9","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0413"},{"key":"S0022149X11000290_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2009.01.026"},{"key":"S0022149X11000290_ref16","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.07.048694"},{"key":"S0022149X11000290_ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3156.2000.00646.x"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X11000290","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T20:37:12Z","timestamp":1556224632000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X11000290\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,8]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["S0022149X11000290"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x11000290","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,8]]}}}