{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:21:53Z","timestamp":1777350113719,"version":"3.51.4"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T00:00:00Z","timestamp":1360627200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammatory bowel disease (IBD) is a chronic relapsing inflammation afflicting any part of the bowel wall as a result of a deregulated and inappropriate immune response. In recent years, experimental and clinical evidence has demonstrated that infection with parasitic worms could protect hosts from IBD. The aims of this study were to determine if the underlying mechanism of the host immune regulation inherent to <jats:italic>Trichinella spiralis<\/jats:italic> infection involves Foxp3-expressing regulatory T cells, and to gain insight about time-related interactions between intestinal nematode infection and induced colitis using an experimental model for ulcerative colitis. Mice were experimentally subjected to acetic acid-induced colitis, which was either preceded or followed by <jats:italic>T. spiralis<\/jats:italic> infection. Assessment of colitis was done by histopathological examination of the colon and determination of pentraxin 3 levels. Immunohistochemistry was done for demonstration of Foxp3-expressing regulatory T cells in colonic tissues. It was evident that <jats:italic>T. spiralis<\/jats:italic> infection ameliorated the severe inflammation induced by acetic acid, evidenced by amelioration of histopathological changes and diminution of pentraxin 3 levels. The amelioration was more pronounced when <jats:italic>T. spiralis<\/jats:italic> infection preceded the induction of colitis. Regarding the immunohistochemical staining of regulatory T cells, <jats:italic>T. spiralis<\/jats:italic> infection induced recruitment of Foxp3-expressing regulatory T cells to areas of inflammation. In conclusion, <jats:italic>T. spiralis<\/jats:italic> regulatory mechanism can improve inflammation of the colon through the \u2018inflammatory\u2013regulatory\u2019 axis. Finally, it would be of great importance to apply these results to the development of new therapeutic approaches for the treatment of ulcerative colitis.<\/jats:p>","DOI":"10.1017\/s0022149x13000059","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T08:46:41Z","timestamp":1360658801000},"page":"210-218","source":"Crossref","is-referenced-by-count":26,"title":["Interactions between <i>Trichinella spiralis<\/i> infection and induced colitis in mice"],"prefix":"10.1017","volume":"88","author":[{"given":"D.S.","family":"Ashour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Othman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Shareef","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.H.","family":"Gaballah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.W.","family":"Mayah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,2,12]]},"reference":[{"key":"S0022149X13000059_ref66","doi-asserted-by":"publisher","DOI":"10.1038\/nature06878"},{"key":"S0022149X13000059_ref65","doi-asserted-by":"publisher","DOI":"10.1126\/science.296.5567.490"},{"key":"S0022149X13000059_ref63","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06890.x"},{"key":"S0022149X13000059_ref61","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.041749"},{"key":"S0022149X13000059_ref60","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.02.016"},{"key":"S0022149X13000059_ref59","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"},{"key":"S0022149X13000059_ref54","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2006.00427.x"},{"key":"S0022149X13000059_ref53","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4417-4423.2001"},{"key":"S0022149X13000059_ref52","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-010-0321-6"},{"key":"S0022149X13000059_ref51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.2009.03019.x"},{"key":"S0022149X13000059_ref49","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i29.4628"},{"key":"S0022149X13000059_ref47","doi-asserted-by":"publisher","DOI":"10.1136\/gut.53.1.99"},{"key":"S0022149X13000059_ref45","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.2001.01260.x"},{"key":"S0022149X13000059_ref44","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20021345"},{"key":"S0022149X13000059_ref41","doi-asserted-by":"publisher","DOI":"10.1038\/nri1183"},{"key":"S0022149X13000059_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2011.06.017"},{"key":"S0022149X13000059_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.08.007"},{"key":"S0022149X13000059_ref35","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.11.5931-5937.2002"},{"key":"S0022149X13000059_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.03.008"},{"key":"S0022149X13000059_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2007.10.011"},{"key":"S0022149X13000059_ref30","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1998.00412.x"},{"key":"S0022149X13000059_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2011.01322.x"},{"key":"S0022149X13000059_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2006.00893.x"},{"key":"S0022149X13000059_ref26","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00654.x"},{"key":"S0022149X13000059_ref25","doi-asserted-by":"publisher","DOI":"10.1159\/000228582"},{"key":"S0022149X13000059_ref24","first-page":"329","article-title":"Host protective immunity to Trichinella spiralis in mice: activation of Th cell subsets and lymphokine secretion in mice expressing different response phenotypes","volume":"74","author":"Grencis","year":"1991","journal-title":"Immunology"},{"key":"S0022149X13000059_ref23","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101074"},{"key":"S0022149X13000059_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq313"},{"key":"S0022149X13000059_ref21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.16.s4.3.x"},{"key":"S0022149X13000059_ref20","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115756"},{"key":"S0022149X13000059_ref56","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02651.x"},{"key":"S0022149X13000059_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2005.12.005"},{"key":"S0022149X13000059_ref7","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1005557"},{"key":"S0022149X13000059_ref37","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.16.1.137"},{"key":"S0022149X13000059_ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011013231802"},{"key":"S0022149X13000059_ref48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03805.x"},{"key":"S0022149X13000059_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.67.3.267"},{"key":"S0022149X13000059_ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.4.2414"},{"key":"S0022149X13000059_ref55","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)00014-X"},{"key":"S0022149X13000059_ref28","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.038"},{"key":"S0022149X13000059_ref43","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091903"},{"key":"S0022149X13000059_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/75015"},{"key":"S0022149X13000059_ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.051407.123757"},{"key":"S0022149X13000059_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2008.11.008"},{"key":"S0022149X13000059_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00191.x"},{"key":"S0022149X13000059_ref9","first-page":"1605","article-title":"Imbalance of CD4(+) T cell subgroups in ulcerative colitis","volume":"91","author":"Chao","year":"2011","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"S0022149X13000059_ref40","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4274(03)00269-8"},{"key":"S0022149X13000059_ref50","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v113.pm9352851"},{"key":"S0022149X13000059_ref62","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001269"},{"key":"S0022149X13000059_ref64","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20042572"},{"key":"S0022149X13000059_ref58","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-009-0091-9"},{"key":"S0022149X13000059_ref13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082460"},{"key":"S0022149X13000059_ref8","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.4.G539"},{"key":"S0022149X13000059_ref57","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00358-07"},{"key":"S0022149X13000059_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.08.011"},{"key":"S0022149X13000059_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2010.12.013"},{"key":"S0022149X13000059_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-2896.2004.00192.x"},{"key":"S0022149X13000059_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-0901-5_7"},{"key":"S0022149X13000059_ref3","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.19576"},{"key":"S0022149X13000059_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2005.02.013"},{"key":"S0022149X13000059_ref10","doi-asserted-by":"publisher","DOI":"10.2307\/3281709"},{"key":"S0022149X13000059_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200940109"},{"key":"S0022149X13000059_ref4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132723"},{"key":"S0022149X13000059_ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000129209"},{"key":"S0022149X13000059_ref19","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19836"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X13000059","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T15:35:53Z","timestamp":1555947353000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X13000059\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,12]]},"references-count":65,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0022149X13000059"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x13000059","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,12]]}}}