{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T02:48:27Z","timestamp":1777430907829,"version":"3.51.4"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T00:00:00Z","timestamp":1373414400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cystic echinococcosis caused by <jats:italic>Echinococcus granulosus<\/jats:italic> sensu lato is one of the most important helminth zoonoses in the world; it affects both humans and livestock. The disease is endemic in Argentina and highly endemic in the province of Neuqu\u00e9n. Considerable genetic and phenotypic variation has been demonstrated in <jats:italic>E. granulosus,<\/jats:italic> and ten different genotypes (G1\u2013G10) have been identified using molecular tools. <jats:italic>Echinococcus granulosus<\/jats:italic> sensu lato may be considered a species complex, comprised of <jats:italic>E. granulosus<\/jats:italic> sensu stricto (G1\u2013G3), <jats:italic>E. equinus<\/jats:italic> (G4), <jats:italic>E. ortleppi<\/jats:italic> (G5) and <jats:italic>E. canadensis<\/jats:italic> (G6\u2013G10). In endemic areas, the characterization of cystic echinococcosis molecular epidemiology is important in order to apply adequate control strategies. A cut-off value for larval large hook total length to distinguish <jats:italic>E. granulosus<\/jats:italic> sensu stricto isolates from those produced by other species of the complex was defined for the first time. Overall, 1780 larval hooks of 36 isolates obtained from sheep (<jats:italic>n<\/jats:italic>=\u00a011, G1), goats (<jats:italic>n<\/jats:italic>=\u00a010, G6), cattle (<jats:italic>n<\/jats:italic>=\u00a05, G6) and pigs (<jats:italic>n<\/jats:italic>=\u00a010, G7) were analysed. Validation against molecular genotyping as gold standard was carried out using the receiver operating characteristic (ROC) curve analysis. The optimum cut-off value was defined as 26.5\u00a0\u03bcm. The proposed method showed high sensitivity (97.8%) and specificity (91.1%). Since in most endemic regions the molecular epidemiology of echinococcosis includes the coexistence of the widely distributed <jats:italic>E. granulosus<\/jats:italic> sensu stricto G1 strain and other species of the complex, this technique could be useful as a quick and economical tool for epidemiological and surveillance field studies, when fertile cysts are present.<\/jats:p>","DOI":"10.1017\/s0022149x13000473","type":"journal-article","created":{"date-parts":[[2013,7,10]],"date-time":"2013-07-10T13:07:09Z","timestamp":1373461629000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["The optimum cut-off value to differentiate <i>Echinococcus granulosus<\/i> sensu stricto from other species of <i>E. granulosus<\/i> sensu lato using larval rostellar hook 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