{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T05:10:06Z","timestamp":1781154606279,"version":"3.54.1"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T00:00:00Z","timestamp":1376956800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The histopathological effects of<jats:italic>Taenia crassiceps<\/jats:italic>infection or<jats:italic>T. crassiceps<\/jats:italic>metacestode factor inoculation on the mouse ovary were determined using six female mice in three groups: infected mice, mice inoculated with the metacestode factor and control mice. The control group was subcutaneously inoculated with healthy peritoneal fluid. The infected group was intraperitoneally inoculated with 40<jats:italic>T. crassiceps<\/jats:italic>metacestodes, and the metacestode factor group was subcutaneously inoculated with<jats:italic>T. crassiceps<\/jats:italic>metacestode factor (MF). Light and electron microscopy and TUNEL (terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end labelling) assays revealed a significant increase in ovarian follicular atresia (predominantly in antral\/preovulatory stages of development), oocyte degeneration (<jats:italic>P<\/jats:italic>&lt;\u00a00.05), and a decrease in the amount of corpus luteum in follicles of mice infected and inoculated with MF compared with the control group. Significant abnormalities of the granulosa cells and oocytes of the primordial, primary and secondary ovarian follicles occurred in both treated mouse groups (<jats:italic>P<\/jats:italic>&lt;\u00a00.05) compared with no degeneration in the control group. These pathological changes in female mice either infected with<jats:italic>T. crassiceps<\/jats:italic>metacestodes or inoculated with<jats:italic>T. crassiceps<\/jats:italic>MF may have consequences for ovulation and fertility.<\/jats:p>","DOI":"10.1017\/s0022149x13000588","type":"journal-article","created":{"date-parts":[[2013,8,20]],"date-time":"2013-08-20T13:40:11Z","timestamp":1377006011000},"page":"49-57","source":"Crossref","is-referenced-by-count":5,"title":["A<i>Taenia crassiceps<\/i>metacestode factor enhances ovarian follicle atresia and oocyte degeneration in female 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