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Parasitological, microbiological, histopathological and immunohistochemical examinations of the liver and lungs were undertaken, and 49 of these organs were infected with cysts. In 14 of 31 (45.1%) livers and 10 of 18 (55.5%) lungs microbial growth was observed. The most frequent species occurring in the liver were<jats:italic>Staphylococcus aureus<\/jats:italic>,<jats:italic>Escherichia coli<\/jats:italic>,<jats:italic>Corynebacterium<\/jats:italic>spp. and<jats:italic>Campylobacter<\/jats:italic>spp., whereas in the lungs the most common species was<jats:italic>Candida<\/jats:italic>spp., followed by<jats:italic>Streptococcus<\/jats:italic>spp.,<jats:italic>Mannheimia haemolytica<\/jats:italic>,<jats:italic>Corynebacterium<\/jats:italic>spp.,<jats:italic>Micrococcus<\/jats:italic>spp. and<jats:italic>S. aureus<\/jats:italic>. The concentration of serum interleukin (IL-6) in infected cattle, 455.35\u00a0\u00b1\u00a039.68\u00a0pg\/ml, was significantly higher than that of 83.02\u00a0\u00b1\u00a017.87\u00a0pg\/ml in the control group (<jats:italic>P<\/jats:italic>&lt;\u00a00.001). The serum amyloid A (SAA) level of infected cattle was 7.51\u00a0\u00b1\u00a00.41\u00a0<jats:roman>\u03bc<\/jats:roman>g\/ml, and 4.84\u00a0\u00b1\u00a00.51\u00a0<jats:roman>\u03bc<\/jats:roman>g\/ml in the control group (<jats:italic>P<\/jats:italic>&lt;\u00a00.001). The serum haptoglobin level of infected cattle was found to be 2.08\u00a0\u00b1\u00a00.65\u00a0ng\/ml, while that of the control group was determined as 3.87\u00a0\u00b1\u00a00.91\u00a0ng\/ml (<jats:italic>P<\/jats:italic>&gt;0.05). The highest concentrations of IL-6 were detected in serum of the cattle where microbial growth had been detected, followed by cattle infected with bacteria +<jats:italic>Trichostrongylus<\/jats:italic>sp. (<jats:italic>P<\/jats:italic>&lt;\u00a00.001). Consequently, SAA showed an important increase in the group infected with hydatid cysts, whereas haptoglobin level decreased. It was noticed that IL-6, like SAA, had a significant role in hydatid cyst infection. Therefore IL-6 and SAA appear to be major markers in the detection of infection of cattle with hydatid cysts.<\/jats:p>","DOI":"10.1017\/s0022149x14000315","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T10:49:07Z","timestamp":1399978147000},"page":"471-479","source":"Crossref","is-referenced-by-count":8,"title":["Acute-phase responses in cattle infected with hydatid cysts and microbial 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