{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T04:55:49Z","timestamp":1788670549010,"version":"build-2803163510"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T00:00:00Z","timestamp":1403136000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human taeniosis due to<jats:italic>Taenia saginata<\/jats:italic>is cosmopolitan where beef is consumed; however, there is little or no information on the symptomatology over the early time-course of human infection. Copro-antigen detection is very useful in community screening for human taeniosis, particularly for<jats:italic>T. solium<\/jats:italic>, but there are no data on copro-antigen detection in pre-patent infection. In order to provide insight into this, a voluntary self-infection with<jats:italic>T. saginata<\/jats:italic>was undertaken and monitored over a 6-month period using a copro-antigen enzyme-linked immunosorbent assay (ELISA) that we developed using anti-<jats:italic>T. saginata<\/jats:italic>antibody based reagents. Tapeworm patency, defined as first proglottid appearance, occurred on day 86 post-infection (pi) and was followed by almost daily release of proglottids (range 1\u20138) until termination using praziquantel on day 180 pi. The first 10 weeks post-infection (wpi) were essentially asymptomatic, followed by main symptoms of involuntary proglottid discharge throughout the infection period, and abdominal discomfort peaking around 15\u201319 wpi. Copro-antigens could not be reliably detected until 2 weeks before proglottid patency but then remained highly elevated over the next 15 weeks until treatment. Copro-antigen levels reverted to negative 4 days post-treatment. This time-course study suggests that although copro-antigen ELISA is an excellent diagnostic tool for established patent infections of<jats:italic>T. saginata<\/jats:italic>, it may not be reliable for faecal antigen detection in the early infection phase prior to proglottid release for<jats:italic>T. saginata<\/jats:italic>and other human taenioses.<\/jats:p>","DOI":"10.1017\/s0022149x14000455","type":"journal-article","created":{"date-parts":[[2014,6,19]],"date-time":"2014-06-19T14:29:54Z","timestamp":1403188194000},"page":"612-619","source":"Crossref","is-referenced-by-count":35,"title":["<i>Taenia saginata<\/i>taeniosis: copro-antigen time-course in a voluntary self-infection"],"prefix":"10.1017","volume":"89","author":[{"given":"A.","family":"Tembo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.S.","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,6,19]]},"reference":[{"key":"S0022149X14000455_ref41","first-page":"337","article-title":"Cysticercosis in swines and bovines, with special reference to South African conditions","volume":"9","author":"Viljoen","year":"1937","journal-title":"Onderstepoort Journal of Veterinary Science and Animal Industry"},{"key":"S0022149X14000455_ref27","volume-title":"Parasites and parasitic infection in early medicine and science","author":"Hoeppli","year":"1953"},{"key":"S0022149X14000455_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2008.01.009"},{"key":"S0022149X14000455_ref44","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.2.548-553.2004"},{"key":"S0022149X14000455_ref23","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4269\/ajtmh.2009.81.433","article-title":"Development of a species-specific coproantigen ELISA for human Taenia solium taeniasis","volume":"81","author":"Guezala","year":"2009","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0022149X14000455_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00931075"},{"key":"S0022149X14000455_ref6","first-page":"545","article-title":"Identification and partial characterization of a myosin-like protein from cysticerci and adults of Taenia solium using a monoclonal antibody","volume":"114","author":"Ambrosio","year":"1997","journal-title":"Parasitology"},{"key":"S0022149X14000455_ref17","doi-asserted-by":"publisher","DOI":"10.3347\/kjp.1992.30.1.21"},{"key":"S0022149X14000455_ref10","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00011585"},{"key":"S0022149X14000455_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.010"},{"key":"S0022149X14000455_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000060686"},{"key":"S0022149X14000455_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S003118200005006X"},{"key":"S0022149X14000455_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000061801"},{"key":"S0022149X14000455_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(97)90042-0"},{"key":"S0022149X14000455_ref7","first-page":"658","volume-title":"Topley and Wilson's microbiology and microbial infections: Parasitology","author":"Andreassen","year":"2005"},{"key":"S0022149X14000455_ref8","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05428-11"},{"key":"S0022149X14000455_ref9","doi-asserted-by":"publisher","DOI":"10.1051\/vetres:2002040"},{"key":"S0022149X14000455_ref11","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1128\/JCM.33.5.1283-1288.1995","article-title":"Isolation and characterisation of species-specific DNA probes from Taenia solium and Taenia saginata and their use in an egg detection assay","volume":"33","author":"Chapman","year":"1995","journal-title":"Journal of Clinical Microbiology"},{"key":"S0022149X14000455_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e3282ef579e"},{"key":"S0022149X14000455_ref28","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182096008074"},{"key":"S0022149X14000455_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(90)90097-U"},{"key":"S0022149X14000455_ref33","volume-title":"WHO\/FAO\/OIE guidelines for surveillance, prevention and control of taeniosis\/cysticercosis","author":"Murrell","year":"2005"},{"key":"S0022149X14000455_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(91)90302-F"},{"key":"S0022149X14000455_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2007.07.004"},{"key":"S0022149X14000455_ref16","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182003004712"},{"key":"S0022149X14000455_ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X00012694"},{"key":"S0022149X14000455_ref19","doi-asserted-by":"crossref","first-page":"850","DOI":"10.4269\/ajtmh.2006.74.850","article-title":"Combined human and porcine mass chemotherapy for the control of T. solium","volume":"74","author":"Garcia","year":"2006","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0022149X14000455_ref20","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1996.55.282"},{"key":"S0022149X14000455_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(87)90365-8"},{"key":"S0022149X14000455_ref25","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000078768"},{"key":"S0022149X14000455_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)01606-4"},{"key":"S0022149X14000455_ref32","doi-asserted-by":"publisher","DOI":"10.2307\/3284613"},{"key":"S0022149X14000455_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.014"},{"key":"S0022149X14000455_ref35","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652006000100010"},{"key":"S0022149X14000455_ref36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0001953"},{"key":"S0022149X14000455_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2005.11.024"},{"key":"S0022149X14000455_ref43","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1999.60.199"},{"key":"S0022149X14000455_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60176-1"},{"key":"S0022149X14000455_ref22","volume-title":"A history of human helminthology","author":"Grove","year":"1990"},{"key":"S0022149X14000455_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(94)00691-5"},{"key":"S0022149X14000455_ref40","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1990.11812513"},{"key":"S0022149X14000455_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91886-1"},{"key":"S0022149X14000455_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2006.11.003"},{"key":"S0022149X14000455_ref31","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182013001005"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X14000455","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T04:59:25Z","timestamp":1597985965000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X14000455\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,19]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0022149X14000455"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x14000455","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,19]]}}}