{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:28:03Z","timestamp":1787826483456,"version":"build-2784847793"},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T00:00:00Z","timestamp":1421193600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Trichinellosis is a zoonotic disease caused by nematode species of the genus <jats:italic>Trichinella<\/jats:italic>. Anthelmintics targeting the intestinal adults and muscle-dwelling larvae of <jats:italic>Trichinella<\/jats:italic> spp. have been tested, with limited success. This study was aimed at determining the efficacy of maslinic acid and fenbendazole on muscle larvae of <jats:italic>Trichinella zimbabwensis<\/jats:italic> in laboratory rats. Forty-two Sprague\u2013Dawley rats, with an average weight of 270\u00a0g and 180\u00a0g for males and females respectively, were infected with <jats:italic>T. zimbabwensis<\/jats:italic> larvae. Infected rats were randomly assigned to three groups which were subjected to single treatments with each of maslinic acid, fenbendazole and a combination of both on day 25 post-infection (pi), and three groups which were subjected to double treatments with each of these drugs and a combination on days 25 and 32 pi. The untreated control group received a placebo. In single-treatment groups, the efficacy of each treatment, measured by rate of reduction in muscle larvae, was significant (<jats:italic>P<\/jats:italic>&lt;\u00a00.001) for both drugs compared to the untreated control group. There was no apparent synergistic effect on the combination of the two drugs in reducing the muscle larval burden, either in single or double treatments. In all the treatment regimens, the reductions were significant (<jats:italic>P<\/jats:italic>&lt;\u00a00.001) when compared to the untreated control and not significant when the single treatments were compared with the double treatments (<jats:italic>P<\/jats:italic>&gt;0.05). We conclude that the efficacy of maslinic acid against larval stages of <jats:italic>T. zimbabwensis<\/jats:italic> in rats was comparable to that of fenbendazole, with no side-effects observed, making maslinic acid a promising anthelmintic against larval stages of <jats:italic>Trichinella<\/jats:italic> species.<\/jats:p>","DOI":"10.1017\/s0022149x14000923","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T07:00:31Z","timestamp":1421218831000},"page":"86-90","source":"Crossref","is-referenced-by-count":9,"title":["Efficacy of maslinic acid and fenbendazole on muscle larvae of <i>Trichinella zimbabwensis<\/i> in laboratory rats"],"prefix":"10.1017","volume":"90","author":[{"given":"S.","family":"Mukaratirwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Gcanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kamau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,1,14]]},"reference":[{"key":"S0022149X14000923_ref23","first-page":"2","volume-title":"Proceedings of the 12th Working Meeting of the Crocodile Specialist Group","volume":"2","author":"Smith","year":"2004"},{"key":"S0022149X14000923_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.07.045"},{"key":"S0022149X14000923_ref21","volume-title":"PROC 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aspects of infection with Trichinella species","volume":"9","author":"Capo","year":"1996","journal-title":"Clinical Microbiology Reviews"},{"key":"S0022149X14000923_ref2","first-page":"93","article-title":"A study of the reproductive capacity of Trichinella spiralis recovered from experimentally infected mice under-dosed with albendazole or mebendazole","volume":"24","author":"De la Rosa","year":"2007","journal-title":"Tropical Biomedicine"},{"key":"S0022149X14000923_ref7","unstructured":"Garcia-Granados A. , Martinez A. , Parra A. & Rivas F. (1998) Process for the industrial recovery of oleanoic and maslinic acids contained in the olive milling subproducts. Patent number WO\/1998\/004-331, University of Granada, Spain."}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X14000923","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T23:46:53Z","timestamp":1555717613000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X14000923\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,14]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0022149X14000923"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x14000923","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,14]]}}}