{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T20:44:42Z","timestamp":1786999482838,"version":"build-2736575974"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T00:00:00Z","timestamp":1425254400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human cystic echinococcosis (CE), caused by\n                    <jats:italic>Echinococcus granulosu<\/jats:italic>\n                    s, is one of the most important and widespread parasitic zoonoses. One of the problems that can be encountered after treating CE patients is the risk of post-surgical relapses or treatment failure, thus a long-term clinical and serological follow-up is required to evaluate the success or failure of therapy. In the present study immunological markers have been identified to indicate the effectiveness of pharmacological and surgical treatments. The relationship between serum cytokine levels and the outcome of chemotherapy and surgery was evaluated in 50 patients with CE. Serum interleukin (IL)-4, IL-10 and interferon-gamma (IFN-\u03b3) concentrations were determined by enzyme-linked immunosorbent assay (ELISA) before and after pharmacological and surgical treatment. Serum cytokine levels of IL-4, IL-10 and IFN-\u03b3 were elevated in a significant proportion of patients during the active stage of disease. IL-4, IL-10 and IFN-\u03b3 were measurable in 41 (82%), 37 (74%) and 25 (50%) patients before the treatment. Clinical and radiological assessment of patients 2 years after pharmacological treatment has shown that 48 of 50 patients responded to treatment. IL-4 and IL-10 levels were decreased significantly (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;\u00a00.05) in these patients. Conversely, patients who did not respond showed high levels of IL-4 and IL-10 and undetectable levels of IFN-\u03b3. Hence these results suggest that serum IL-4 and IL-10 detection may be useful in the follow-up of patients with CE.\n                  <\/jats:p>","DOI":"10.1017\/s0022149x15000085","type":"journal-article","created":{"date-parts":[[2015,3,2]],"date-time":"2015-03-02T04:06:15Z","timestamp":1425269175000},"page":"91-95","source":"Crossref","is-referenced-by-count":15,"title":["Detection of serum cytokines before and after pharmacological and surgical treatment in patients with cystic echinococcosis"],"prefix":"10.1017","volume":"90","author":[{"given":"M.I.","family":"Naik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.K.","family":"Tenguria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,3,2]]},"reference":[{"key":"S0022149X15000085_ref30","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.10.6679"},{"key":"S0022149X15000085_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2006.00060.x"},{"key":"S0022149X15000085_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00230-9"},{"key":"S0022149X15000085_ref25","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2012.01383.x"},{"key":"S0022149X15000085_ref16","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00843.x"},{"key":"S0022149X15000085_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb05569.x"},{"key":"S0022149X15000085_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00682.x"},{"key":"S0022149X15000085_ref11","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/781649"},{"key":"S0022149X15000085_ref8","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2009161057"},{"key":"S0022149X15000085_ref7","first-page":"355","volume-title":"The biology of Echinococcus and hydatid disease","author":"McManus","year":"1995"},{"key":"S0022149X15000085_ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.1997.d01-173.x"},{"key":"S0022149X15000085_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(96)00638-9"},{"key":"S0022149X15000085_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5699(05)80015-5"},{"key":"S0022149X15000085_ref20","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.4049\/jimmunol.147.8.2713","article-title":"Production of IL-10 by CD4+T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection","volume":"15","author":"Sher","year":"1991","journal-title":"Journal of Immunology"},{"key":"S0022149X15000085_ref28","first-page":"231","article-title":"Guidelines for treatment of cystic and alveolar echinococcosis in humans","volume":"74","year":"1996","journal-title":"Bulletin of the World Health Organization"},{"key":"S0022149X15000085_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2009.11.001"},{"key":"S0022149X15000085_ref21","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.8.1679"},{"key":"S0022149X15000085_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1995.tb03778.x"},{"key":"S0022149X15000085_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(02)00225-5"},{"key":"S0022149X15000085_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(89)90724-4"},{"key":"S0022149X15000085_ref17","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.1.288-296.2001"},{"key":"S0022149X15000085_ref6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4269\/ajtmh.2008.79.301","article-title":"Clinical management of cystic echinococcosis: state of the art, problems and perspectives","volume":"79","author":"Junghanss","year":"2008","journal-title":"American Journal of Tropical Medicine and Hygiene"},{"key":"S0022149X15000085_ref23","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1996.d01-843.x"},{"key":"S0022149X15000085_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.2011.01335.x"},{"key":"S0022149X15000085_ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.01021.x"},{"key":"S0022149X15000085_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(97)00055-7"},{"key":"S0022149X15000085_ref24","doi-asserted-by":"publisher","DOI":"10.1089\/jir.1997.17.211"},{"key":"S0022149X15000085_ref27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1993.tb04182.x"},{"key":"S0022149X15000085_ref22","doi-asserted-by":"publisher","DOI":"10.1259\/0007-1285-63-751-523"},{"key":"S0022149X15000085_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1995.tb01008.x"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X15000085","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T10:46:11Z","timestamp":1717757171000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X15000085\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["S0022149X15000085"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x15000085","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,2]]}}}