{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T00:03:44Z","timestamp":1717891424378},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study was undertaken to determine whether a parasite substance produces structural pathology in the mouse spleen. A low-molecular-weight<jats:italic>Taenia crassiceps<\/jats:italic>metacestode factor (MF) isolated from the peritoneal fluid of female mice infected with<jats:italic>T. crassiceps<\/jats:italic>metacestodes induced pathological and immunological changes in mouse spleen cells<jats:italic>in vivo.<\/jats:italic>Electron microscopy and confocal microscopy revealed severe changes in the spleen histoarchitecture of<jats:italic>T. crassiceps<\/jats:italic>-infected and MF-treated mice. Apoptotic degenerated spleen cells were observed in the white and red pulps and were more conspicuous in the white pulp of the spleen from the<jats:italic>T. crassiceps<\/jats:italic>-infected mice than in that of the MF-treated mice. Flow cytometry analysis revealed that the numbers of spleen CD4+T cells were significantly lower in both experimental groups than in control mice. The<jats:italic>ex vivo<\/jats:italic>expression of transforming growth factor (TGF)-\u03b2 and factor Foxp3 were significantly higher in splenocytes of the experimental mice than the basal expression observed in the control cells. These findings may have potential applications for a better understanding of the host\u2013parasite relationship in human neurocysticercosis.<\/jats:p>","DOI":"10.1017\/s0022149x1500022x","type":"journal-article","created":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T11:52:31Z","timestamp":1428493951000},"page":"223-231","source":"Crossref","is-referenced-by-count":5,"title":["A<i>Taenia crassiceps<\/i>factor induces apoptosis of spleen CD4+T cells and TFG-\u03b2 and<i>Foxp3<\/i>gene expression in mice"],"prefix":"10.1017","volume":"90","author":[{"given":"N.","family":"Zepeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Tirado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Copitin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Solano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Tato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.L.","family":"Molinari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,4,8]]},"reference":[{"key":"S0022149X1500022X_ref30","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1365-2222.2009.03442.x","article-title":"Multiple T cell epitope peptides suppress allergic responses in an egg allergy mouse model by the elicitation of forkhead box transcription factor 3- and transforming growth factor-beta-associated mechanisms","volume":"40","author":"Yang","year":"2010","journal-title":"Clinical and Experimental Allergy"},{"key":"S0022149X1500022X_ref5","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2001.01579.x"},{"key":"S0022149X1500022X_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050379"},{"key":"S0022149X1500022X_ref7","first-page":"27","volume-title":"Cysticercosis of the central nervous system","author":"Escobar","year":"1983"},{"key":"S0022149X1500022X_ref18","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/498583"},{"key":"S0022149X1500022X_ref22","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1128\/IAI.63.6.2277-2281.1995","article-title":"Depressed T-cell proliferation associated with susceptibility to experimental Taenia crassiceps infection","volume":"63","author":"Sciutto","year":"1995","journal-title":"Infection and Immunity"},{"key":"S0022149X1500022X_ref10","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.4049\/jimmunol.143.10.3230","article-title":"Transforming growth factor-beta inhibits the generation of cytotoxic T cells in virus-infected mice","volume":"143","author":"Fontana","year":"1989","journal-title":"Journal of Immunology"},{"key":"S0022149X1500022X_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/BF00274046"},{"key":"S0022149X1500022X_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/00034983.1990.11812458"},{"key":"S0022149X1500022X_ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041659"},{"key":"S0022149X1500022X_ref8","doi-asserted-by":"publisher","DOI":"10.1645\/GE-3255"},{"key":"S0022149X1500022X_ref23","first-page":"204","article-title":"Cytokine profiles in paraffin-embedded biopsy samples of lepromatous leprosy patients: semi-quantitative measure of cytokine mRNA using RT-PCR","volume":"3","author":"Shabaana","year":"2001","journal-title":"International Journal of Leprosy and Other Mycobacterial Diseases"},{"key":"S0022149X1500022X_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.03.013"},{"key":"S0022149X1500022X_ref2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0076-6879(57)03350-9","volume-title":"Methods in enzymology","author":"Ashwell","year":"1957"},{"key":"S0022149X1500022X_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-4017(97)00173-8"},{"key":"S0022149X1500022X_ref24","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X13000588"},{"key":"S0022149X1500022X_ref12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101074"},{"key":"S0022149X1500022X_ref29","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050170"},{"key":"S0022149X1500022X_ref28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00937107","article-title":"Suppression of murine lymphocyte proliferation induced by a small RNA purified from the Taenia solium metacestode","volume":"81","author":"Tato","year":"1995","journal-title":"Parasitology Research"},{"key":"S0022149X1500022X_ref14","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.4049\/jimmunol.146.11.4016","article-title":"Transforming growth factor-beta suppresses human B lymphocyte Ig production by inhibiting synthesis and the switch from the membrane form to the secreted form of Ig mRNA","volume":"146","author":"Kehri","year":"1991","journal-title":"Journal of Immunology"},{"key":"S0022149X1500022X_ref16","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1993.49.502"},{"key":"S0022149X1500022X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2006.09.006"},{"key":"S0022149X1500022X_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636751"},{"key":"S0022149X1500022X_ref31","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.07.008"},{"key":"S0022149X1500022X_ref13","doi-asserted-by":"publisher","DOI":"10.1084\/jem.163.5.1037"},{"key":"S0022149X1500022X_ref3","doi-asserted-by":"publisher","DOI":"10.1038\/nature04753"},{"key":"S0022149X1500022X_ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050367"},{"key":"S0022149X1500022X_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"S0022149X1500022X_ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2000.00301.x"},{"key":"S0022149X1500022X_ref6","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030152"},{"key":"S0022149X1500022X_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0159-2"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X1500022X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,8]],"date-time":"2024-06-08T08:01:41Z","timestamp":1717833701000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X1500022X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,8]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S0022149X1500022X"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x1500022x","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,8]]}}}