{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:30:58Z","timestamp":1762252258314},"reference-count":23,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T00:00:00Z","timestamp":1437609600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In the present paper, we analyse the effect of a primary infection of ICR mice with <jats:italic>Echinostoma caproni<\/jats:italic> (Trematoda: Echinostomatidae) on the generation of resistance against homologous challenge infections. In ICR mice, <jats:italic>E. caproni<\/jats:italic> induces chronic infections concomitantly with strong responses characterized by the development of T-helper 1 (Th1)-type local immune responses with elevated levels of local interferon-gamma (IFN-\u03b3) and inflammatory and antibody responses. Here, the effect of the response generated against a primary infection with <jats:italic>E. caproni<\/jats:italic> in the generation of resistance against subsequent homologous infections was analysed. For this purpose, ICR mice were challenged with metacercariae of <jats:italic>E. caproni<\/jats:italic> and the results obtained showed that primary infection induces partial resistance against subsequent homologous infections in ICR mice. This resistance was expressed as a reduced rate of infection, worm recovery and worm size, indicating that primary infection induces changes in the host, making a hostile environment for the development of the parasite.<\/jats:p>","DOI":"10.1017\/s0022149x1500053x","type":"journal-article","created":{"date-parts":[[2015,7,23]],"date-time":"2015-07-23T04:34:11Z","timestamp":1437626051000},"page":"428-433","source":"Crossref","is-referenced-by-count":8,"title":["Partial resistance to homologous challenge infections of the digenean <i>Echinostoma caproni<\/i> in ICR mice"],"prefix":"10.1017","volume":"90","author":[{"given":"C.","family":"Mu\u00f1oz-Antoli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cort\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mart\u00edn-Grau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Fried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Esteban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,7,23]]},"reference":[{"key":"S0022149X1500053X_ref8","doi-asserted-by":"publisher","DOI":"10.2307\/3282482"},{"key":"S0022149X1500053X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(09)69003-5"},{"key":"S0022149X1500053X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2005.04.006"},{"key":"S0022149X1500053X_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/BF00932183"},{"key":"S0022149X1500053X_ref9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.803-805.2006"},{"key":"S0022149X1500053X_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2010.09.004"},{"key":"S0022149X1500053X_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00932705"},{"key":"S0022149X1500053X_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.12.009"},{"key":"S0022149X1500053X_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2007.02.008"},{"key":"S0022149X1500053X_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000000949"},{"key":"S0022149X1500053X_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-004-1161-1"},{"key":"S0022149X1500053X_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.01.006"},{"key":"S0022149X1500053X_ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.4.2424"},{"key":"S0022149X1500053X_ref10","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902879"},{"key":"S0022149X1500053X_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-308X(08)60037-8"},{"key":"S0022149X1500053X_ref14","first-page":"192","article-title":"Further studies on the population regulation in Echinostoma caproni infections in NMRI mice","volume":"56","author":"Odaibo","year":"1989","journal-title":"Proceedings of the Helminthological Society of Washington"},{"key":"S0022149X1500053X_ref13","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1091R.1"},{"key":"S0022149X1500053X_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.08.004"},{"key":"S0022149X1500053X_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s004360050167"},{"key":"S0022149X1500053X_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.08.014"},{"key":"S0022149X1500053X_ref4","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1294.1"},{"key":"S0022149X1500053X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2011.03.010"},{"key":"S0022149X1500053X_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(86)90186-4"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X1500053X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T22:11:54Z","timestamp":1555625514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X1500053X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,23]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["S0022149X1500053X"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x1500053x","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,23]]}}}