{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:24:31Z","timestamp":1767151471683,"version":"build-2238731810"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Excretory\u2013secretory (ES) products of nematodes and other helminths are the first molecules to interact with cell surfaces and soluble proteins within the host. In the present study, ES products of the filarial nematode\n                    <jats:italic>Onchocerca ochengi<\/jats:italic>\n                    were investigated as a model for\n                    <jats:italic>Onchocerca volvulus<\/jats:italic>\n                    , the causative agent of river blindness. These products were collected from adult and larval stages\n                    <jats:italic>in vitro<\/jats:italic>\n                    over a period of 7 days, to compare their immunological recognition in cattle and human sera, infected with species of\n                    <jats:italic>Onchocerca<\/jats:italic>\n                    . From the 156 sodium dodecyl sulphate polyacrylamide gel electrophoresis (SDS-PAGE) ES products or extracts, protein bands showed different patterns between female and male products. A comparison of antibody recognition of the different ES products by sera from infected cattle and humans, when analysed by enzyme-linked immunosorbent assay (ELISA), revealed a relatively higher reactivity of the female somatic extract to human and cattle sera compared to ES products of both genders. Nevertheless, similar reactivity of the\n                    <jats:italic>O. ochengi<\/jats:italic>\n                    male and female ES products to human and cattle sera was noticed. As a result, the interaction of ES products with the surface of the host and immune system often led to host responses, including the generation of antibodies. The\n                    <jats:italic>O. ochengi<\/jats:italic>\n                    ES products are therefore good sources of potential immunogenic proteins. The identification of these ES products is in progress, with the aim of developing vaccine candidates against human onchocerciasis.\n                  <\/jats:p>","DOI":"10.1017\/s0022149x15000796","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T22:47:33Z","timestamp":1441925253000},"source":"Crossref","is-referenced-by-count":1,"title":["RETRACTED \u2013 Immune recognition of excretory and secretory products of the filarial nematode\n                    <i>Onchocerca ochengi<\/i>\n                    in cattle and human sera"],"prefix":"10.1017","volume":"94","author":[{"given":"B.","family":"Djafsia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ndjonka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.V.","family":"Dikti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"van Hoorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Manchang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Brattig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Liebau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"S0022149X15000796_ref4","doi-asserted-by":"publisher","DOI":"10.1179\/000349804225003253"},{"key":"S0022149X15000796_ref15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068380"},{"key":"S0022149X15000796_ref8","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.2005.24.283"},{"key":"S0022149X15000796_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1992.tb03070.x"},{"key":"S0022149X15000796_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60942-8"},{"key":"S0022149X15000796_ref12","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.9.5348"},{"key":"S0022149X15000796_ref20","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X14000224"},{"key":"S0022149X15000796_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2012.11.011"},{"key":"S0022149X15000796_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/0169-4758(86)90138-9"},{"key":"S0022149X15000796_ref7","first-page":"1","article-title":"Obligatory symbiotic Wolbachia endobacteria are absent from Loa loa","volume":"2","author":"B\u00fcttner","year":"2003","journal-title":"Filarial Journal"},{"key":"S0022149X15000796_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.05.013"},{"key":"S0022149X15000796_ref28","doi-asserted-by":"publisher","DOI":"10.2174\/138955706775475984"},{"key":"S0022149X15000796_ref30","unstructured":"Soblik, H. 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