{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:09:52Z","timestamp":1763017792762},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T00:00:00Z","timestamp":1500336000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Soil-transmitted helminthiasis (STH) is caused by <jats:italic>Ascaris lumbricoides<\/jats:italic> (roundworm), <jats:italic>Trichuris trichiura<\/jats:italic> (whipworm), and <jats:italic>Ancylostoma duodenale<\/jats:italic> and <jats:italic>Necator americanus<\/jats:italic> (hookworms). Mebendazole is one of the recommended preventive chemotherapy agents for STH. This review summarizes the efficacy data from 29 studies with single-dose 500 mg mebendazole in STH treatment and compares the results with those of a recently conducted phase 3 study of a 500 mg mebendazole chewable tablet against <jats:italic>A. lumbricoides<\/jats:italic> and <jats:italic>T. trichiura<\/jats:italic> infections. Studies that reported efficacy results against at least one STH infection were selected from the literature and efficacy data by each STH type were abstracted and pooled. Single-dose 500 mg mebendazole treatment resulted in a cure rate of 92.6% (range: 72.5\u2013100%) for <jats:italic>A. lumbricoides,<\/jats:italic> 27.6% (range: 8.4\u2013100%) for <jats:italic>T. trichiura<\/jats:italic> and 25.5% (range: 2.9\u201391.1%) for hookworms. Egg reduction rate for <jats:italic>A. lumbricoides<\/jats:italic> was 97.9% (range: 89.8\u2013100%), for <jats:italic>T. trichiura<\/jats:italic> it was 72.9% (range: 31.6\u201393.0%) and for hookworms it was 72.0% (range: \u22126.5% (denoting an increase in egg count) to 98.3%). Similar results were observed in the studies that were placebo-controlled. In the phase 3 study, the cure rate and egg reduction rate reported was 83.7% and 97.9%, respectively, for <jats:italic>A. lumbricoides<\/jats:italic> and 33.9% and 59.7%, respectively, for <jats:italic>T. trichiura<\/jats:italic>. In conclusion, single-dose 500 mg mebendazole showed a high cure rate against <jats:italic>A. lumbricoides<\/jats:italic> and a substantial reduction in faecal egg count for all STH types. These results are consistent with the recently conducted phase 3 study of a new 500 mg chewable mebendazole tablet.<\/jats:p>","DOI":"10.1017\/s0022149x17000426","type":"journal-article","created":{"date-parts":[[2017,7,18]],"date-time":"2017-07-18T04:28:00Z","timestamp":1500352080000},"page":"269-278","source":"Crossref","is-referenced-by-count":13,"title":["Efficacy of single-dose 500 mg mebendazole in soil-transmitted helminth infections: a review"],"prefix":"10.1017","volume":"92","author":[{"given":"J.","family":"Mrus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Baeten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Engelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Silber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,7,18]]},"reference":[{"key":"S0022149X17000426_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"S0022149X17000426_ref10","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.1997.57.25"},{"key":"S0022149X17000426_ref43","unstructured":"WHO (2015) Soil-transmitted helminth infections. 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