{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T15:28:48Z","timestamp":1759159728377},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2017,11,6]],"date-time":"2017-11-06T00:00:00Z","timestamp":1509926400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Gnathostoma turgidum<\/jats:italic>is a nematode parasite that exploits the stomach of Virginian opossums,<jats:italic>Didelphis virginiana,<\/jats:italic>in Latin America. The opossum is the definitive host of<jats:italic>G. turgidum<\/jats:italic>in the wild. Intrahepatic growth and maturation of the parasite, subsequent migration to the stomach and spontaneous expulsion are common. However, the histopathological lesions caused by<jats:italic>G. turgidum<\/jats:italic>are poorly described. A better understanding of the life cycle of this parasite and the pathological changes in natural host\u2013parasite interactions could help to clarify the progression of human infections caused by<jats:italic>Gnathostoma binucleatum<\/jats:italic>. The aim of this work was to study morphological changes in the liver and stomach of<jats:italic>D. virginiana<\/jats:italic>during natural infection and adult worm expulsion. Three opossums naturally infected with<jats:italic>G. turgidum<\/jats:italic>were captured from an endemic area of gnathostomosis. Three uninfected opossums captured from a non-endemic area were used as controls. The opossums were sacrificed at different stages of infection (March, May and December), and a histopathological study of their livers and stomachs was conducted. Injuries in livers were observed by histopathology \u2013 areas of necrosis and collagen septa were identified. Parasites caused nodules with necrosis on the periphery of lesions, and collagen fibres were also observed in stomachs. Collagen septa may be caused by antigenic remains of the parasite. Further immunological studies are necessary to verify that stimulation is caused by these factors.<\/jats:p>","DOI":"10.1017\/s0022149x17000980","type":"journal-article","created":{"date-parts":[[2017,11,5]],"date-time":"2017-11-05T22:57:22Z","timestamp":1509922642000},"page":"765-768","source":"Crossref","is-referenced-by-count":3,"title":["Histopathological changes in the liver and stomach of<i>Didelphis virginiana<\/i>(Didelphimorphia: Didelphidae) during natural infection with<i>Gnathostoma turgidum<\/i>(Nematoda: Gnathostomidae)"],"prefix":"10.1017","volume":"92","author":[{"given":"E.H.","family":"Torres-Montoya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Zazueta-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.U.","family":"Osuna-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Castillo-Ureta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Silva-Hidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.S.","family":"L\u00f3pez-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Osuna-Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Noguera-Corona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.G.","family":"Rend\u00f3n-Maldonado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2017,11,6]]},"reference":[{"key":"S0022149X17000980_ref2","first-page":"17","article-title":"Aspectos cl\u00ednicos y de diagn\u00f3stico de la gnathostomosis experimental caniana","volume":"43","author":"\u00c1lvarez-Guerrero","year":"2012","journal-title":"Veterinaria M\u00e9xico"},{"key":"S0022149X17000980_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2009.10.023"},{"key":"S0022149X17000980_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2010.04.004"},{"key":"S0022149X17000980_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2006.09.008"},{"key":"S0022149X17000980_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X07850231"},{"key":"S0022149X17000980_ref6","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.03.003"},{"key":"S0022149X17000980_ref8","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1988.1"},{"key":"S0022149X17000980_ref9","doi-asserted-by":"crossref","unstructured":"P\u00e9rez-\u00c1lvarez Y , Garc\u00eda-Prieto L , Osorio-Sarabia D , Lamothe-Argumedo R , and Le\u00f3n-R\u00e8ganon V (2008) Present distribution of the genus Gnathostoma (Nematoda: Gnathostomatidae) in M\u00e9xico. Zootaxa 12 November, 39\u201355.","DOI":"10.11646\/zootaxa.1930.1.3"},{"key":"S0022149X17000980_ref11","doi-asserted-by":"publisher","DOI":"10.7589\/2013-04-092"},{"key":"S0022149X17000980_ref1","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2000)086[0537:IRSOGS]2.0.CO;2"},{"key":"S0022149X17000980_ref3","doi-asserted-by":"publisher","DOI":"10.1645\/GE-1871.1"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X17000980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T13:00:44Z","timestamp":1570280444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X17000980\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["S0022149X17000980"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x17000980","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,6]]}}}