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Intraperitoneal infection with <jats:italic>T. crassiceps<\/jats:italic> metacestodes or subcutaneous inoculation with a <jats:italic>T. crassiceps<\/jats:italic> metacestode factor (Fac) produced significant impairment of performance (learning) in the Barnes maze and induced bilateral hippocampal sclerosis in mice. Several staining techniques revealed important cell dispersion, extensive apoptosis and cell loss in the dentate gyrus, hilus and CA1-CA3 regions of both hippocampi, as well as intense deterioration of the adjacent cortex. An outstanding disruption of its histoarchitecture in the surrounding tissue of all these regions and apoptosis of the endothelial cells were also observed.<\/jats:p>","DOI":"10.1017\/s0022149x18000755","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T11:22:19Z","timestamp":1535023339000},"page":"690-696","source":"Crossref","is-referenced-by-count":7,"title":["Hippocampal sclerosis induced in mice by a <i>Taenia crassiceps<\/i> metacestode 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