{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T11:06:09Z","timestamp":1759230369697,"version":"3.40.5"},"reference-count":17,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>A novel microfilarial sheath protein (MfP) of the human filarial parasite <jats:italic>Wuchereria bancrofti<\/jats:italic> and its proinflammatory activity on host macrophages were identified recently. MfP is a homolog of the nematode bestrophin-9 superfamily that acts as a ligand of macrophage Toll-like receptor 4 (TLR4) to induce inflammation through NF-\u03baB activation. Therefore, the presence and functional implication of this novel protein in adult-stage parasites were open questions to answer. In this study, the bovine filarial parasite <jats:italic>Setaria cervi<\/jats:italic> was used to simulate adult <jats:italic>W. bancrofti<\/jats:italic>. We detected the presence of MfP in adult-stage <jats:italic>S. cervi<\/jats:italic> through clear immunological cross-reactivity and immunolocalization employing an anti-MfP antibody developed in mice. Therefore, our findings put forward <jats:italic>S. cervi<\/jats:italic> as a cost-effective source of immunodominant filarial antigen MfP to simulate its future utilization in the immunotherapeutic intervention of lymphatic filariasis.<\/jats:p>","DOI":"10.1017\/s0022149x18001050","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T03:44:44Z","timestamp":1543290284000},"source":"Crossref","is-referenced-by-count":5,"title":["Exploring the homolog of a novel proinflammatory microfilarial sheath protein (MfP) of <i>Wuchereria bancrofti<\/i> in the adult-stage bovine filarial parasite <i>Setaria cervi<\/i>"],"prefix":"10.1017","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5709-9190","authenticated-orcid":false,"given":"S.","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-0377","authenticated-orcid":false,"given":"N.","family":"Joardar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7441-6426","authenticated-orcid":false,"given":"S.P.","family":"Sinha Babu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"S0022149X18001050_ref14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.1.322"},{"key":"S0022149X18001050_ref12","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12389"},{"key":"S0022149X18001050_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2015.10.011"},{"key":"S0022149X18001050_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2013.11.006"},{"key":"S0022149X18001050_ref11","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jix067"},{"key":"S0022149X18001050_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/pim.12081"},{"key":"S0022149X18001050_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60586-7"},{"key":"S0022149X18001050_ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3024.2001.00394.x"},{"key":"S0022149X18001050_ref16","unstructured":"WHO (World Health Organization) (2016) Lymphatic filariasis. Available at http:\/\/www.who.int\/mediacentre\/factsheets\/fs102\/en (accessed 6 October 2017)."},{"key":"S0022149X18001050_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-010-0009-3"},{"key":"S0022149X18001050_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-30610-7"},{"key":"S0022149X18001050_ref8","doi-asserted-by":"publisher","DOI":"10.3109\/08820138709030571"},{"volume-title":"Allergic Diseases: Highlights in the Clinic, Mechanisms and Treatment","year":"2012","author":"Araujo","key":"S0022149X18001050_ref2"},{"key":"S0022149X18001050_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2012.10.011"},{"key":"S0022149X18001050_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2009.01.006"},{"key":"S0022149X18001050_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000066397"},{"key":"S0022149X18001050_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.10.114"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X18001050","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T01:08:20Z","timestamp":1571620100000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X18001050\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":17,"alternative-id":["S0022149X18001050"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x18001050","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"type":"print","value":"0022-149X"},{"type":"electronic","value":"1475-2697"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"article-number":"e15"}}