{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T11:25:10Z","timestamp":1783855510920,"version":"3.55.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>New therapeutic approaches are necessary to control strongyloidiasis due to the side effects of, and resistance to, currently available drugs thiabendazole, albendazole, and ivermectin. This study examined the anthelmintic properties of extracts and isolated compounds from<jats:italic>Siparuna guianensis<\/jats:italic>against<jats:italic>Strongyloides venezuelensis<\/jats:italic>eggs and larvae, using the egg hatching test (EHT) and larval motility test (LMT). Albendazole (0.025 mg\/ml) and ivermectin (0.316 mg\/ml) were used as the positive controls for the EHT and LMT assays, respectively.<jats:italic>Strongyloides venezuelensis<\/jats:italic>eggs or larvae (\u00b150 specimens) were treated with ethanol extract (0.05\u20131.0 mg\/ml), ethyl acetate and aqueous fractions (0.05\u20130.8 mg\/ml), essential oil (0.2\u20131.0 mg\/ml) and \u03b1-bisabolol (0.2\u20131.0 mg\/ml) from<jats:italic>S. guianensis<\/jats:italic>, and analysed by optical microscopy after 48 h (EHT), or after 24, 48 and 72 h (LMT). All the tested compounds exhibited ovicidal activity equivalent to the positive control and changed the morphology of the eggs. The<jats:italic>S. guianensis<\/jats:italic>ethanol extract and aqueous fraction were as effective as the positive control. Phytochemical analysis of the ethanol extract and fractions revealed the presence of phenolic compounds, tannins and flavonoids. Therefore,<jats:italic>S. guianensis<\/jats:italic>is effective against<jats:italic>S. venezuelensis<\/jats:italic>eggs and larvae<jats:italic>in vitro<\/jats:italic>, and can be considered as a potential alternative treatment for strongyloidiasis.<\/jats:p>","DOI":"10.1017\/s0022149x19000282","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T19:20:20Z","timestamp":1555010420000},"source":"Crossref","is-referenced-by-count":20,"title":["In vitro anthelmintic activity of<i>Siparuna guianensis<\/i>extract and essential oil against<i>Strongyloides venezuelensis<\/i>"],"prefix":"10.1017","volume":"94","author":[{"given":"V.F.","family":"Carvalho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. dos A.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"da 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