{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:34:30Z","timestamp":1773038070465,"version":"3.50.1"},"reference-count":37,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between epilepsy and the presence of visceral larva migrans caused by<jats:italic>Toxocara canis<\/jats:italic>in Mexican children remains uncertain; however, this relationship needs to be elucidated because these parasite larvae can invade the human central nervous system. Accordingly, this study aimed to determine the frequency and specificity of anti-<jats:italic>T. canis<\/jats:italic>antibodies in the sera of children with epilepsy to determine the relationship between this parasite and epilepsy. The sera samples of 214 children were examined: 111 children diagnosed with epilepsy and 103 clinically healthy children without neurological disorders. In the sera of each group, the presence and specificity of anti-<jats:italic>T. canis<\/jats:italic>and anti-<jats:italic>Ascaris lumbricoides<\/jats:italic>antibodies, as well as the cross-reactivity between them, were assessed using enzyme-linked immunosorbent assay and Western blotting analysis. Among the children with epilepsy, 25.2% exhibited seropositivity to<jats:italic>T. canis<\/jats:italic>. Cross-reactivity against the<jats:italic>A. lumbricoides<\/jats:italic>antigen was present in 46.8% of the children with epilepsy, whereas 11.7% of the children with epilepsy and anti-<jats:italic>T. canis<\/jats:italic>antibodies did not exhibit cross-reactivity against this antigen. The Western blotting analysis of the sera from the children with epilepsy demonstrated the presence of<jats:italic>T. canis<\/jats:italic>proteins, with molecular weights of 24, 35, 55, 70, 120 and 210 kDa, and<jats:italic>A lumbricoides<\/jats:italic>proteins with molecular weights of 70, 80 and 110 kDa. Our results revealed the presence of anti-<jats:italic>T. canis<\/jats:italic>antibodies in the children with epilepsy; furthermore, cross-reactivity tests with<jats:italic>A. lumbricoides<\/jats:italic>showed the importance of the presence of anti-<jats:italic>T. canis<\/jats:italic>antibodies in revealing the relationship between this parasite and epilepsy in children.<\/jats:p>","DOI":"10.1017\/s0022149x1900083x","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T09:08:56Z","timestamp":1569229736000},"source":"Crossref","is-referenced-by-count":2,"title":["Frequency of<i>Toxocara canis<\/i>antibodies in Mexican paediatric patients with epilepsy"],"prefix":"10.1017","volume":"94","author":[{"given":"M.d.L.","family":"Caballero-Garc\u00eda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sim\u00f3n-Salvador","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Hern\u00e1ndez-Aguilar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Reyes-Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Nogueda-Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5151-7048","authenticated-orcid":false,"given":"E.","family":"Jim\u00e9nez-Cardoso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"S0022149X1900083X_ref32","doi-asserted-by":"publisher","DOI":"10.1081\/IMM-120022974"},{"key":"S0022149X1900083X_ref31","first-page":"475","article-title":"Contaminaci\u00f3n 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