{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:53:39Z","timestamp":1747173219641,"version":"3.40.5"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"unspecified","delay-in-days":56,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2020]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ascariasis is a neglected tropical disease, caused by<jats:italic>Ascaris lumbricoides<\/jats:italic>, affecting 800 million people worldwide. Studies focused on the early stage of parasite infection, occurring in the gut, liver and lungs, require the use of a mouse model. In these models, the porcine ascarid,<jats:italic>Ascaris suum<\/jats:italic>, is often used. The results obtained from these studies are then used to draw conclusions about<jats:italic>A. lumbricoides<\/jats:italic>infections in humans. In the present study, we sought to compare larval migration of<jats:italic>A. suum<\/jats:italic>and<jats:italic>A. lumbricoides<\/jats:italic>in mouse models. We used a previously developed mouse model of ascariasis, which consists of two mouse strains, where one mouse strain \u2013 C57BL\/6J \u2013 is a model for relative susceptibility and the other \u2013 CBA\/Ca \u2013 for relative resistance. Mice of both strains were infected with either<jats:italic>A. suum<\/jats:italic>or<jats:italic>A. lumbricoides<\/jats:italic>. The larval burden was assessed in two key organs, the liver and lungs, starting at 6 h post infection (p.i.) and ending on day 8 p.i. Additionally, we measured the larval size of each species (\u03bcm) at days 6, 7 and 8 p.i. in the lungs. We found that larval burden in the liver is significantly higher for<jats:italic>A. lumbricoides<\/jats:italic>than for<jats:italic>A. suum<\/jats:italic>. However, the inverse is true in the lungs. Additionally, our results showed a reduced larval size for<jats:italic>A. lumbricoides<\/jats:italic>compared to<jats:italic>A. suum<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0022149x20000127","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T12:42:06Z","timestamp":1582720926000},"source":"Crossref","is-referenced-by-count":6,"title":["<i>Ascaris lumbricoides<\/i>and<i>Ascaris suum<\/i>vary in their larval burden in a mouse 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