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Given the important role of oxidative stress and immune-mediated inflammation in the pathogenesis of trichinellosis, this study was designed to evaluate the possible protective effects of resveratrol (RSV) during the intestinal and muscular phases of<jats:italic>Trichinella spiralis<\/jats:italic>infection in mice. The oral administration of RSV at a dose of 20\u00a0mg\/kg once daily for two weeks resulted in significant reductions in both adult and larval counts; significant improvements in the redox status of the small intestine and muscles; a significant reduction in interleukin 4, pentraxin 3 and vascular endothelial growth factor expression; and the mitigation of intestinal and muscular inflammation. In conclusion, this study identifies RSV as a promising agent for the treatment of experimental trichinellosis, and more studies in experimental animals and humans are worth consideration.<\/jats:p>","DOI":"10.1017\/s0022149x20000206","type":"journal-article","created":{"date-parts":[[2020,4,2]],"date-time":"2020-04-02T03:58:52Z","timestamp":1585799932000},"source":"Crossref","is-referenced-by-count":33,"title":["Resveratrol reduces oxidative damage and inflammation in mice infected with<i>Trichinella spiralis<\/i>"],"prefix":"10.1017","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-6113","authenticated-orcid":false,"given":"D.I.","family":"Elgendy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Othman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Hasby 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