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As unique inflammation modulator of intracellular parasitism,<jats:italic>Trichinella spiralis<\/jats:italic>, or its excretory\u2013secretory (ES) product, shows improved responses to allergies, autoimmune diseases, inflammatory bowel disease, type 1 diabetes, rheumatic arthritis and autoimmune encephalomyelitis by exerting immunomodulatory effects on both innate and adaptive immune cells in animal models. Research has shown that<jats:italic>T. spiralis<\/jats:italic>differs from other helminths in manipulation of the host immune response not only by well-known characteristics of its life cycle, but also by its inflammation modulation pathway. How the parasite achieves inflammation modulation has not been fully elucidated yet. 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