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In the liver, the most infected organ, the larvae co-occurred with the coccidian <jats:italic>Goussia<\/jats:italic> sp. Within the granuloma around the <jats:italic>A. simplex<\/jats:italic> (<jats:italic>s.s.<\/jats:italic>) larvae, two concentric layers were recognized, an inner mostly comprising electron-dense epithelioid cells and an outer layer made of less electron-dense epithelioid cells. Macrophages and macrophage aggregates (MAs) were abundant out of the granulomas, scattered in parenchyma, and inside the MAs, the presence of engulfed <jats:italic>Goussia<\/jats:italic> sp. was frequent. In liver tissue co-infected with <jats:italic>Goussia<\/jats:italic> sp. and <jats:italic>A. simplex<\/jats:italic> (<jats:italic>s.s.<\/jats:italic>), hepatocytes showed cytoplasmic rarefaction and acute cell swelling. Results suggest that the host-induced encapsulation of <jats:italic>A. simplex<\/jats:italic> (<jats:italic>s.s.<\/jats:italic>) larvae is a strategic compromise to minimize collateral tissue damage around the larval infection sites, to facilitate the survival of both parasite and host.<\/jats:p>","DOI":"10.1017\/s0022149x20000942","type":"journal-article","created":{"date-parts":[[2021,3,10]],"date-time":"2021-03-10T10:12:59Z","timestamp":1615371179000},"source":"Crossref","is-referenced-by-count":17,"title":["Immunohistopathological response against anisakid nematode larvae and a coccidian in <i>Micromesistius poutassou<\/i> from NE Atlantic waters"],"prefix":"10.1017","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-5937","authenticated-orcid":false,"given":"B.","family":"Sayyaf 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