{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:40:34Z","timestamp":1757702434050,"version":"3.40.5"},"reference-count":54,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T00:00:00Z","timestamp":1621900800000},"content-version":"unspecified","delay-in-days":144,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2021]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Trichinellosis is a zoonotic disease that endangers human health and can lead to death. Restricted absorption and poor results of conventional therapies demand new effective natural remedies to treat both enteral and parenteral trichinellosis. This study assessed the antiparasitic and anti-inflammatory effects of <jats:italic>Citrus limon<\/jats:italic> and <jats:italic>Capsicum frutescens<\/jats:italic> on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis. Overall, 50 Swiss albino male mice were divided into five groups, with ten mice in each group: negative control, positive control, albendazole combined with prednisolone, <jats:italic>C. limon,<\/jats:italic> and <jats:italic>C. frutescens<\/jats:italic>. Mice were sacrificed 7 and 35 days after infection, for intestinal and muscular phase analyses. Drug efficacies were parasitologically, biochemically, histopathologically and ultrastructurally assessed. Our results demonstrated the efficacy of <jats:italic>C. frutescens<\/jats:italic> and <jats:italic>C. limon<\/jats:italic> extracts as antiparasitic agents, showing a substantial decrease in adult and larval counts. Moreover, both extracts had the ability to decrease serum tumour necrosis factor-\u03b1 levels during the intestinal and muscular phases. In addition to the improved histopathological changes in the small intestine and muscles, the destructive effects on adults and larvae were ultrastructurally evident on transmission electron microscopy. In conclusion, <jats:italic>C. frutescens<\/jats:italic> and <jats:italic>C. limon<\/jats:italic> extracts are promising remedies for the treatment of experimental trichinellosis, particularly, the <jats:italic>C. frutescens<\/jats:italic> extract.<\/jats:p>","DOI":"10.1017\/s0022149x21000171","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T06:12:17Z","timestamp":1621923137000},"source":"Crossref","is-referenced-by-count":5,"title":["<i>Capsicum frutescens<\/i> and <i>Citrus limon<\/i>: a new take on therapy against experimental trichinellosis"],"prefix":"10.1017","volume":"95","author":[{"given":"Marwa Ahmed Mohamed","family":"Salama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahed E.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naglaa Fathy","family":"Abd El-Aal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman M.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar Kamel","family":"Hammad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha","family":"Adel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4815-5576","authenticated-orcid":false,"given":"Howayda Said Fouad","family":"Moawad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2021,5,25]]},"reference":[{"key":"S0022149X21000171_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2010.04.017"},{"key":"S0022149X21000171_ref49","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2551-9"},{"key":"S0022149X21000171_ref2","unstructured":"Alvarado, R. , Meza, L. , Garc\u00eda, M. , Sald\u00edvar, S. & Moreno, G. 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