{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:32:46Z","timestamp":1790800366275,"version":"4.1.0"},"reference-count":117,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"unspecified","delay-in-days":348,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2023]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Trichinellosis is a re-emerging worldwide foodborne zoonosis. Oxidative stress is one of the most common detrimental effects caused by trichinellosis. In addition, <jats:italic>Trichinella<\/jats:italic> infection poses an infinite and major challenge to the host\u2019s immune system. Resistance and side effects limit the efficiency of the existing anti-<jats:italic>trichinella<\/jats:italic> medication. Given that concern, this work aimed to investigate the anti-helminthic, antioxidant, anti-inflammatory and immunomodulatory effects of resveratrol and zinc during both phases of <jats:italic>Trichinella spiralis<\/jats:italic> infection. Sixty-four Swiss albino mice were divided into four equal groups: non-infected control, infected control, infected and treated with resveratrol, and infected and treated with zinc. Animals were sacrificed on the 7th and 35th days post-infection for intestinal and muscular phase assessments. Drug efficacy was assessed by biochemical, parasitological, histopathological, immunological, and immunohistochemical assays. Resveratrol and zinc can be promising antiparasitic, antioxidant, anti-inflammatory, and immunomodulatory agents, as evidenced by the significant decrease in parasite burden, the significant improvement of liver and kidney function parameters, the increase in total antioxidant capacity (TAC), the reduction of malondialdehyde (MDA) level, the increase in nuclear factor (erythroid-derived 2)-like-2 factor expression, and the improvement in histopathological findings. Moreover, both drugs enhanced the immune system and restored the disturbed immune balance by increasing the interleukin 12 (IL-12) level. In conclusion, resveratrol and zinc provide protection for the host against oxidative harm and the detrimental effects produced by the host\u2019s defense response during <jats:italic>Trichinella spiralis<\/jats:italic> infection, making them promising natural alternatives for the treatment of trichinellosis.<\/jats:p>","DOI":"10.1017\/s0022149x23000810","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T09:52:07Z","timestamp":1702633927000},"source":"Crossref","is-referenced-by-count":10,"title":["Impact of resveratrol and zinc on biomarkers of oxidative stress induced by <i>Trichinella spiralis<\/i> infection"],"prefix":"10.1017","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7950-4719","authenticated-orcid":false,"given":"M.A.","family":"Salama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6006-3711","authenticated-orcid":false,"given":"M.A.","family":"Alabiad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"S0022149X23000810_r75","article-title":"Selenium\/zinc-enriched probiotics improve serum enzyme activity, antioxidant ability, inflammatory factors and related gene expression of Wistar rats inflated under heat stress","volume":"117464","author":"Malyar","year":"2020","journal-title":"Life Sciences"},{"key":"S0022149X23000810_r86","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3390\/antiox8060164","article-title":"Molecular mechanisms of zinc as a pro-antioxidant mediator: clinical therapeutic implications","volume":"8","author":"Prasad","year":"2019","journal-title":"Antioxidants"},{"key":"S0022149X23000810_r82","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s00436-009-1533-7","article-title":"In vitro effects of resveratrol on T. spiralis","volume":"105","author":"Ozkoc","year":"2009","journal-title":"Parasitology Research"},{"key":"S0022149X23000810_r47","doi-asserted-by":"crossref","first-page":"53","DOI":"10.7150\/ijms.35977","article-title":"Protective effects of resveratrol supplementation on contusion induced muscle injury","volume":"17","author":"Hsu","year":"2020","journal-title":"International Journal of Medical Sciences"},{"key":"S0022149X23000810_r53","first-page":"56","article-title":"Antioxidative, anti-inflammatory and hepatoprotective effects of resveratrol on oxidative stress-induced liver damage in tilapia (Oreochromis niloticus)","volume":"215","author":"Jia","year":"2019","journal-title":"Comparative Biochemistry and Physiology Part C: Toxicology and Pharmacology"},{"key":"S0022149X23000810_r69","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1186\/s13071-016-1662-7","article-title":"Evaluation of protective efficacy induced by virus-like particles containing a Trichinella spiralis excretory-secretory (ES) protein in mice","volume":"9","author":"Lee","year":"2016","journal-title":"Parasites and Vectors"},{"key":"S0022149X23000810_r3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/B978-0-12-803620-4.00017-7","volume-title":"A comprehensive guide to toxicology in nonclinical drug development","author":"Aulbach","year":"2017"},{"key":"S0022149X23000810_r36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00436-008-1160-8","article-title":"Oxidative-antioxidant status of Fasciola hepatica-infected rats supplemented with zinc. 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