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The medications used in the management of trichinellosis demonstrate inadequate bioavailability, along with a significant level of resistance. Therefore, there is a need for the development of novel agents that enhance the bioavailability of administered medications. Nanobiotechnology has emerged as a significant strategy in treating parasitic diseases. This study examined the use of solid lipid nanoparticles (SLNs) to improve the efficacy of oral ivermectin (IVM) in treating the enteric phase of trichinellosis. Thirty-five Swiss albino mice were divided into seven equal groups as follows: negative control, positive control, albendazole, ivermectin, SLNs, ivermectin loaded on solid lipid nanoparticles (IVM-SLNs), and a combination of IVM-SLNs and albendazole. Mice were sacrificed on the seventh day post-infection. The drugs\u2019 effects were assessed using parasitological, biochemical, histological, histochemical and immunohistochemical analyses. The co-administration of albendazole and IVM-SLNs resulted in a significant decrease in adult burden, inflammatory cell infiltration, and apoptosis. Furthermore, a significant reduction in Cyclooxygenase-2 (COX-2) expression was observed compared to the infected untreated control group, along with improved liver and kidney function indices. In conclusion, the potent trichinocidal effect of a single oral dose of IVM-SLNs against <jats:italic>Trichinella<\/jats:italic> adults makes them a promising alternative or adjunct to existing nematicidal agents.<\/jats:p>","DOI":"10.1017\/s0022149x2500029x","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T08:41:43Z","timestamp":1745311303000},"source":"Crossref","is-referenced-by-count":3,"title":["The impact of ivermectin-loaded solid lipid nanoparticles on the enteric phase of experimental trichinellosis"],"prefix":"10.1017","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7869-5696","authenticated-orcid":false,"given":"S.K.","family":"Hammad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.H.","family":"Almotayam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.N.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.I.","family":"Farag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"S0022149X2500029X_r50","first-page":"857","volume-title":"Clinical Biochemistry of Domestic Animals","author":"Kaneko","year":"1997"},{"key":"S0022149X2500029X_r79","first-page":"773","article-title":"Role of \u03b1-chymotrypsin and colchicine as adjuvant therapy in experimental muscular trichinellosis: parasitological, biochemical and immunohistochemical study","volume":"15","author":"Shoheib","year":"2006","journal-title":"Egyptian Journal of Bacteriology"},{"key":"S0022149X2500029X_r84","first-page":"352","article-title":"Measurement of creatinine by Jaffe\u2019s reaction - Determination of concentration of sodium hydroxide required for maximum color development in standard, urine and protein free filtrate of serum","volume":"40","author":"Toora","year":"2002","journal-title":"Indian Journal of Experimental Biology"},{"key":"S0022149X2500029X_r3","doi-asserted-by":"publisher","DOI":"10.17582\/journal.aavs\/2021\/9.9.1376.1382"},{"key":"S0022149X2500029X_r57","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-015-0260-7"},{"key":"S0022149X2500029X_r71","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2011.05.019"},{"key":"S0022149X2500029X_r24","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(71)90365-2"},{"key":"S0022149X2500029X_r21","doi-asserted-by":"publisher","DOI":"10.1007\/s004180050367"},{"key":"S0022149X2500029X_r78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.06.140"},{"key":"S0022149X2500029X_r7","first-page":"190","article-title":"Effects of ivermectin and albendazole on some liver and kidney function indices in rats","volume":"3","author":"Arise","year":"2008","journal-title":"African Journal of Biochemistry Research"},{"key":"S0022149X2500029X_r29","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X20000206"},{"key":"S0022149X2500029X_r37","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.13.2.156"},{"key":"S0022149X2500029X_r18","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-04609-4_13"},{"key":"S0022149X2500029X_r61","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(01)00105-3"},{"key":"S0022149X2500029X_r63","doi-asserted-by":"publisher","DOI":"10.1007\/s12639-024-01756-1"},{"key":"S0022149X2500029X_r10","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2016.021"},{"key":"S0022149X2500029X_r67","doi-asserted-by":"publisher","DOI":"10.21608\/jesp.2018.76543"},{"key":"S0022149X2500029X_r73","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2007.07.002"},{"key":"S0022149X2500029X_r75","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-013-3339-x"},{"key":"S0022149X2500029X_r42","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)57021-6"},{"key":"S0022149X2500029X_r80","doi-asserted-by":"publisher","DOI":"10.5152\/tpd.2011.22"},{"key":"S0022149X2500029X_r88","unstructured":"WHO (2021) Foodborne parasitic infections: Trichinellosis (trichinosis). 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