{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:35:39Z","timestamp":1790134539784,"version":"4.0.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"unspecified","delay-in-days":167,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Haemonchosis is a fatal disease of livestock caused by <jats:italic>Haemonchus contortus<\/jats:italic> (HC) \u2013 a blood-sucking parasite of the abomasum. This parasite is quite prevalent in sheep, causing mortality and production losses. The <jats:italic>suppressor of cytokine signalling-2<\/jats:italic> (<jats:italic>SOCS2<\/jats:italic>) gene plays a vital role in sheep\u2019s immune response against gastrointestinal parasites. This study aimed to estimate the parasitic load of HC in three sheep breeds (Balkhi, Ghalji, and Michni) through faecal egg count and to identify SNPs in the <jats:italic>SOCS2<\/jats:italic> gene associated with the susceptibility of sheep against HC. The results showed that the mean number of HC eggs per gram (EPG) was higher in the faecal samples of Ghalji (4022 \u00b1 1162 EPG), followed by Michni (1988 \u00b1 367 EPG), while the HC EPG was the lowest in Balkhi sheep (1535 \u00b1 552 eggs\/gm). Sequencing results showed polymorphisms in the <jats:italic>SOCS2<\/jats:italic> gene between the low-infection and high-infection categories of the three sheep breeds. A total number of six genic variants were observed, of which three were SNPs, one was insertion, and two were deletions. Polymorphisms were observed in the intronic and 3\u2032 UTR regions of the <jats:italic>SOCS2<\/jats:italic> gene. A deletion (c.1083delGCA) in intron 1 and an insertion (c.3304insT) in intron 2 showed positive correlations (0.833 and 0.889, respectively) with the HC infection, while one SNP in the 3\u2032 UTR region showed negative correlation (\u20130.654). This study provides a basis for selecting resistant sheep against HC infection based on the <jats:italic>SOCS2<\/jats:italic> gene molecular markers.<\/jats:p>","DOI":"10.1017\/s0022149x25100308","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T13:36:21Z","timestamp":1750167381000},"source":"Crossref","is-referenced-by-count":1,"title":["Association of sequence variation in <i>SOCS2<\/i> gene with susceptibility to Heamonchus contortus infection in sheep"],"prefix":"10.1017","volume":"99","author":[{"given":"M.","family":"Tahir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7767-1748","authenticated-orcid":false,"given":"M.","family":"Ibrahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yaqoob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.J.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,6,17]]},"reference":[{"key":"S0022149X25100308_r1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/162158"},{"key":"S0022149X25100308_r4","article-title":"Haemonchosis: A challenging parasitic infection of sheep and goats","volume":"11","author":"Arsenopoulos","year":"2021","journal-title":"Animals (Basel)"},{"key":"S0022149X25100308_r6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.09.007"},{"key":"S0022149X25100308_r14","doi-asserted-by":"publisher","DOI":"10.3390\/ani12101238"},{"key":"S0022149X25100308_r12","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-6150-y"},{"key":"S0022149X25100308_r16","doi-asserted-by":"publisher","DOI":"10.1186\/1297-9686-41-46"},{"key":"S0022149X25100308_r17","first-page":"460","article-title":"Sheep breeds raised under a subtropical environment revealed differential disease patterns and DNA damage","volume":"19","author":"Ibrahim","year":"2023","journal-title":"Journal of Xi\u2019an Shiyou University, Natural Science 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helminth-induced intestinal mastocytosis","volume":"147","author":"Madden","year":"1991","journal-title":"The Journal of Immunology"},{"key":"S0022149X25100308_r10","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7519(89)90019-2"},{"key":"S0022149X25100308_r2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.vetpar.2010.05.001","article-title":"Comparison of parasitological and productive traits of Criollo lambs native to the central Mexican Plateau and Suffolk lambs experimentally infected with Haemonchus contortus","volume":"172","author":"Alba-Hurtado","year":"2010","journal-title":"Veterinary Parasitology"},{"key":"S0022149X25100308_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.livsci.2019.08.005"},{"key":"S0022149X25100308_r21","doi-asserted-by":"crossref","first-page":"1433264","DOI":"10.1155\/2024\/1433264","article-title":"Prevalence and associated risk factors of Haemonchus contortus in sheep slaughtered at Bahir Dar Municipal Abattoir, Ethiopia","volume":"2024","author":"Regassa","year":"2024","journal-title":"Journal of Parasitology Research"},{"key":"S0022149X25100308_r11","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27051534"},{"key":"S0022149X25100308_r8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-7-178"},{"key":"S0022149X25100308_r7","doi-asserted-by":"crossref","first-page":"e00094","DOI":"10.1016\/j.parepi.2019.e00094","article-title":"A survey of Haemonchus contortus parasite of sheep from Gharb plain, Morocco","volume":"4","author":"Brik","year":"2019","journal-title":"Parasite Epidemiology and Control"},{"key":"S0022149X25100308_r5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2016.03.007"},{"key":"S0022149X25100308_r15","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4017(92)90081-J"},{"key":"S0022149X25100308_r3","first-page":"577","article-title":"Haemonchus contortus-sheep relationship: A 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