{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:01:11Z","timestamp":1792684871014,"version":"4.5.0"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"unspecified","delay-in-days":259,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Ulcerative colitis (UC), a chronic recurrent inflammation of the colonic mucosa, has become a global emergency. With the restricted response and significant side effects of traditional drugs, a search for alternatives is mandatory. The current study aimed to evaluate the therapeutic effects of hydatid cyst fluid (HCF) and laminated layer (HLL) derived crude extract of <jats:italic>E. granulosus<\/jats:italic>, combined with the standard medication sulfasalazine (SLZ), for treating acetic acid-induced colitis. Mice were divided into 7 groups. A colitis model using acetic acid (150 \u03bcl of 5% con.) intrarectally was induced. On the 8th day following colitis induction, the mice were sacrificed. We assessed the severity of colitis using survival rate, disease activity index, colon weight\/length ratio, colon weight\/bodyweight ratio, and gross and histopathological score of colon damage. Immunohistochemistry for Foxp3 T-reg expression in colonic tissues was done. The levels of inflammatory cytokines tumor necrosis factor-\u03b1 and IL-10, oxidative stress marker malondialdehyde, and total antioxidant capacity in serum samples were assessed. Groups treated with a combination of SLZ+HCF and SLZ+HLL revealed a statistically significant improvement compared to the colitis group by improving disease activity index, colon weight\/length ratio and colon weight\/bodyweight ratio, and gross and histopathological colon damage scores. Additionally, there was a significant rise in IL-4, TAC, and Foxp3+ Treg cell expression and decreased TNF-\u03b1 and MDA expression. <jats:italic>E. granulosus<\/jats:italic>-derived HCF and HLL potentiate the protective effect of SLZ by increasing anti-inflammatory and antioxidant properties against murine colitis, suggesting the potential for novel therapeutic approaches.<\/jats:p>","DOI":"10.1017\/s0022149x25100345","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T11:35:33Z","timestamp":1758108933000},"source":"Crossref","is-referenced-by-count":1,"title":["Hydatid cyst derived molecules potentiate the protective effect of sulfasalazine in murine induced colitis: Role of FOXP3 T-regulatory cells in colonic tissues"],"prefix":"10.1017","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8902-0834","authenticated-orcid":false,"given":"A.M.","family":"Darwish","sequence":"first","affiliation":[{"name":"Zagazig 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