{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:22:03Z","timestamp":1775218923873,"version":"3.50.1"},"reference-count":69,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"unspecified","delay-in-days":208,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>Trichinellosis is a global foodborne zoonotic disease. Numerous drugs used in its treatment exhibit inadequate absorption and diminished efficacy against encysted larvae in muscle tissue. Therefore, there is a need for innovative therapeutic agents to treat trichinellosis. <jats:italic>Allium sativum (A. sativum)<\/jats:italic>, commonly known as garlic, is a bulbous plant that has been historically utilized in the treatment of various ailments. Currently, there is a paucity of data regarding the in vivo efficacy of <jats:italic>A. sativum<\/jats:italic> against trichinellosis. This study assessed the antiparasitic, anti-inflammatory, and antiapoptotic effects of <jats:italic>A. sativum<\/jats:italic> in murine models, independently or in conjunction with albendazole (ABZ), against the intestinal and muscular stages of trichinellosis. Fifty mice were equally categorized into five groups: negative control, positive control, ABZ, <jats:italic>A. sativum<\/jats:italic>, and a combination of ABZ and <jats:italic>A. sativum.<\/jats:italic> The effectiveness of the examined drugs was assessed through parasitological, biochemical, histological, and immunohistochemical methodologies. <jats:italic>A. sativum<\/jats:italic> resulted in a significant reduction of adult counts by 39.7% and larval counts by 54.4%. The inflammatory cellular infiltrate in the intestine and muscle was significantly reduced. In mice treated with <jats:italic>A. sativum<\/jats:italic>, serum levels of IFN-\u03b3 exhibited a significant increase, accompanied by a rise in Bcl-2 expression and a notable decrease in COX-2 expression. In conclusion, <jats:italic>A. sativum<\/jats:italic> demonstrates potential as a therapeutic agent for treating experimental trichinellosis, particularly during the muscle phase of the disease. It may serve as a safe promising therapy for trichinellosis.<\/jats:p>","DOI":"10.1017\/s0022149x25100539","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T09:57:01Z","timestamp":1753696621000},"source":"Crossref","is-referenced-by-count":1,"title":["Assessment of the therapeutic impact of <i>Allium sativum<\/i> against the intestinal and intramuscular stages of murine 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