{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:23:14Z","timestamp":1785414194725,"version":"3.56.0"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T00:00:00Z","timestamp":1764892800000},"content-version":"unspecified","delay-in-days":338,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2025]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Strongyloides stercoralis<\/jats:italic>\n                    infection affects approximately 600 million individuals worldwide. This parasite has the ability to exacerbate infection through internal autoinfection, which can lead to hyperinfection and\/or dissemination, conditions associated with high morbidity and mortality, particularly in immunocompromised patients such as those with alcohol use disorder (AUD). In this study, we conducted a meta-analysis to assess the prevalence and risk of having\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    infection among individuals with AUD. Searches were performed in the PubMed, Embase, and LILACS databases to identify studies investigating the prevalence of\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    infection in individuals with AUD, with or without comparison to non-alcoholic groups. The pooled prevalence was calculated using the Probit Logit (PLOGIT) transformation, and the odds ratio (OR) was used for risk comparison. The initial search yielded 154 studies, of which seven were included in the systematic review and meta-analysis. The combined prevalence of\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    infection among patients with AUD was 16.9%. Risk analysis based on four studies showed that individuals with AUD had a 6.08-fold higher risk of infection compared with non-alcoholic individuals. These findings highlight chronic alcoholism as a significant risk factor for strongyloidiasis, likely due to a combination of environmental, physiological, and immunological factors. This meta-analysis underscores the critical need for routine screening for\n                    <jats:italic>S. stercoralis<\/jats:italic>\n                    infection in patients with AUD, even in the absence of clinical symptoms, to ensure early detection and timely intervention.\n                  <\/jats:p>","DOI":"10.1017\/s0022149x25100953","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T11:33:41Z","timestamp":1764934421000},"source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and risk of having\n                    <i>Strongyloides stercoralis<\/i>\n                    infection in alcoholic patients: a systematic review and meta-analysis"],"prefix":"10.1017","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0960-0120","authenticated-orcid":false,"given":"G.J.R.","family":"Machado","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Bahia: Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1427-2937","authenticated-orcid":false,"given":"M.R. de M.","family":"Sampaio","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Bahia: Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8091-0780","authenticated-orcid":false,"given":"C.P.","family":"Alves","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Bahia: Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5201-2275","authenticated-orcid":false,"given":"J.L.S.","family":"da Silva","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Bahia: Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1456-9009","authenticated-orcid":false,"given":"J.N.","family":"de Souza","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Bahia: Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1409-9884","authenticated-orcid":false,"given":"N.M.","family":"Soares","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03k3p7647","id-type":"ROR","asserted-by":"publisher"}],"name":"Federal University of Bahia: Universidade Federal da Bahia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,12,5]]},"reference":[{"key":"S0022149X25100953_r49","doi-asserted-by":"publisher","DOI":"10.1590\/S0037-86822002000600004"},{"key":"S0022149X25100953_r1","first-page":"1076","article-title":"Influence of alcohol on gastrointestinal motility: lactulose breath hydrogen testing in orocecal transit time in chronic alcoholics, social drinkers and teetotaler subjects","volume":"44","author":"Addolorato","year":"1997","journal-title":"Hepato-Gastroenterology"},{"key":"S0022149X25100953_r10","doi-asserted-by":"publisher","DOI":"10.1081\/IPH-120003404"},{"key":"S0022149X25100953_r28","doi-asserted-by":"publisher","DOI":"10.1016\/j.trstmh.2008.01.020"},{"key":"S0022149X25100953_r47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2024.03.119"},{"key":"S0022149X25100953_r36","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2024.101754"},{"key":"S0022149X25100953_r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.10.005"},{"key":"S0022149X25100953_r14","article-title":"Strongyloides stercoralis in alcoholic patients: implications of alcohol intake in the frequency of infection and parasite load","volume":"9","author":"de Souza","year":"2020","journal-title":"Pathogens (Basel, Switzerland)"},{"key":"S0022149X25100953_r21","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2018.10.006"},{"key":"S0022149X25100953_r32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000456"},{"key":"S0022149X25100953_r4","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.09.001"},{"key":"S0022149X25100953_r39","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(19)30231-2"},{"key":"S0022149X25100953_r24","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-014-0033-8"},{"key":"S0022149X25100953_r7","doi-asserted-by":"publisher","DOI":"10.1111\/add.16456"},{"key":"S0022149X25100953_r22","first-page":"571","article-title":"Effect of chronic ethanol consumption on protective T-helper 1 and T-helper 2 immune responses against the parasites Leishmania major and Strongyloides stercoralis in mice","volume":"25","author":"Krolewiecki","year":"2001","journal-title":"Alcoholism, Clinical and Experimental Research"},{"key":"S0022149X25100953_r3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0737"},{"key":"S0022149X25100953_r26","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3398"},{"key":"S0022149X25100953_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2019.106128"},{"key":"S0022149X25100953_r40","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2015.11.010"},{"key":"S0022149X25100953_r41","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X17001110"},{"key":"S0022149X25100953_r34","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02067-05"},{"key":"S0022149X25100953_r11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2006.00084.x"},{"key":"S0022149X25100953_r31","first-page":"97","article-title":"Focus on: Alcohol and the immune system","volume":"33","author":"Molina","year":"2010","journal-title":"Alcohol Research and Health: The Journal of the National Institute on Alcohol Abuse and Alcoholism"},{"key":"S0022149X25100953_r43","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2008.00842.x"},{"key":"S0022149X25100953_r46","doi-asserted-by":"publisher","DOI":"10.1007\/BF01297141"},{"key":"S0022149X25100953_r48","first-page":"e46908","article-title":"Strongyloides stercoralis infection in humans: A narrative review of the most neglected parasitic disease","volume":"15","author":"Yeh","year":"2023","journal-title":"Cureus"},{"key":"S0022149X25100953_r6","first-page":"468","article-title":"The Global Prevalence of Strongyloides stercoralis Infection","volume":"9","author":"Buonfrate","year":"2020","journal-title":"Pathogens (Basel, Switzerland)"},{"key":"S0022149X25100953_r2","doi-asserted-by":"publisher","DOI":"10.4067\/S0716-07201999000300005"},{"key":"S0022149X25100953_r45","doi-asserted-by":"publisher","DOI":"10.1007\/s12639-019-01090-x"},{"key":"S0022149X25100953_r8","doi-asserted-by":"publisher","DOI":"10.1111\/j.0141-9838.2004.00726.x"},{"key":"S0022149X25100953_r12","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2016.10.013"},{"key":"S0022149X25100953_r15","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed7110371"},{"key":"S0022149X25100953_r18","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2018.06.007"},{"key":"S0022149X25100953_r29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000717"},{"key":"S0022149X25100953_r20","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138103"},{"key":"S0022149X25100953_r38","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.23-0645"},{"key":"S0022149X25100953_r42","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2021.02.010"},{"key":"S0022149X25100953_r9","first-page":"14","article-title":"Estrongiloidiasis en pacientes alcoh\u00f3licos y m\u00e9todos diagn\u00f3sticos","volume":"1","author":"Catarinella","year":"1992","journal-title":"Rev. costarric. salud p\u00fablica"},{"key":"S0022149X25100953_r44","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4872473"},{"key":"S0022149X25100953_r35","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page MJ, McKenzie","year":"2021","journal-title":"BMJ"},{"key":"S0022149X25100953_r37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002288"},{"key":"S0022149X25100953_r33","doi-asserted-by":"publisher","DOI":"10.1007\/s11686-021-00484-3"},{"key":"S0022149X25100953_r16","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01958-05"},{"key":"S0022149X25100953_r5","first-page":"8","article-title":"Ocorr\u00eancia de Strongyloides stercoralis e demais enteroparasitos em indiv\u00edduos provenientes de munic\u00edpios da regi\u00e3o norte do Paran\u00e1","volume":"16","author":"Bosqui","year":"2014","journal-title":"Biosa\u00fade"},{"key":"S0022149X25100953_r13","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762002000100021"},{"key":"S0022149X25100953_r19","unstructured":"JBI Critical Appraisal Tools | JBI (2022). https:\/\/jbi.global\/critical-appraisal-tools (accessed 30 January 2025)"},{"key":"S0022149X25100953_r25","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.3398"},{"key":"S0022149X25100953_r27","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-010-0150-z"},{"key":"S0022149X25100953_r30","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5056314"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X25100953","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T11:33:56Z","timestamp":1764934436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X25100953\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":49,"alternative-id":["S0022149X25100953"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x25100953","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e128"}}