{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:17:14Z","timestamp":1785417434459,"version":"3.56.0"},"reference-count":23,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"unspecified","delay-in-days":176,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100016912","name":"Merck Sharp and Dohme France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Anthelmintic resistance (AR) in gastrointestinal nematodes is insufficiently studied in cattle in many European regions, including France, where only three studies have been conducted in the north-west. This study evaluated the efficacy of benzimidazoles and avermectins in cattle from a mid-mountain region in central France. Faecal egg count reduction tests (FECRT) were performed in 22 groups of 10\u201325 calves from 16 dairy or beef farms. Each group received either oral oxfendazole (OFZ, 11 groups) or injectable ivermectin (IVM, 11 groups). Faecal samples were collected in a paired study design before (D\n                    <jats:sub>0<\/jats:sub>\n                    ) and after treatment (D\n                    <jats:sub>10-14<\/jats:sub>\n                    for OFZ, D\n                    <jats:sub>14-17<\/jats:sub>\n                    for IVM). Individual faecal egg counts (FECs) were determined using the Mini-FLOTAC method, and pooled faecal samples were cultured per group to determine the proportions of\n                    <jats:italic>Ostertagia<\/jats:italic>\n                    and\n                    <jats:italic>Cooperia<\/jats:italic>\n                    larvae using droplet digital PCR. Efficacy classification (resistant, susceptible or inconclusive) was determined for each group according to the WAAVP guidelines, using the fecrt.com web application and the clinical protocol scenario with a grey zone of 90\u201399%. IVM resistance was detected on 10 of 11 farms, with 33\u201349% and 51\u201367% of larvae being\n                    <jats:italic>Ostertagia<\/jats:italic>\n                    and\n                    <jats:italic>Cooperia<\/jats:italic>\n                    after treatment, respectively. The remaining farm had inconclusive results. OFZ resistance was detected on 2 of 11 farms, with 100% and 97% of larvae being\n                    <jats:italic>Ostertagia<\/jats:italic>\n                    after treatment. The remaining 9 farms were classified as susceptible. This study provides valuable local insights into AR, which could help raise awareness among farmers and veterinarians and encourage changes in treatment practices.\n                  <\/jats:p>","DOI":"10.1017\/s0022149x26101746","type":"journal-article","created":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:43:27Z","timestamp":1782449007000},"source":"Crossref","is-referenced-by-count":0,"title":["Anthelmintic resistance of gastrointestinal nematodes in cattle herds in mid-mountain central France"],"prefix":"10.1017","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1211-8498","authenticated-orcid":false,"given":"L.","family":"Dravigney","sequence":"first","affiliation":[{"name":"Haute Auvergne Veterinary Clinic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2926-3563","authenticated-orcid":false,"given":"C.","family":"Chartier","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q0ncs32","id-type":"ROR","asserted-by":"publisher"}],"name":"BIOEPAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Grelaud","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q0ncs32","id-type":"ROR","asserted-by":"publisher"}],"name":"BIOEPAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0297-4907","authenticated-orcid":false,"given":"T.","family":"Jozan","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/00kt5kp12","id-type":"ROR","asserted-by":"publisher"}],"name":"MSD Animal Health"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Ledieu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q0ncs32","id-type":"ROR","asserted-by":"publisher"}],"name":"BIOEPAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4690-9388","authenticated-orcid":false,"given":"M.","family":"Lopez","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q0ncs32","id-type":"ROR","asserted-by":"publisher"}],"name":"BIOEPAR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"H\u00f6glund","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02yy8x990","id-type":"ROR","asserted-by":"publisher"}],"name":"Swedish University of Agricultural Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3331-0385","authenticated-orcid":false,"given":"N.","family":"Ravinet","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05q0ncs32","id-type":"ROR","asserted-by":"publisher"}],"name":"BIOEPAR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"S0022149X26101746_r11","first-page":"31","article-title":"Refugia-based strategies for parasite control in livestock","volume":"36","author":"Greer","year":"2020","journal-title":"Veterinary Clinics: Food Animal Practice"},{"key":"S0022149X26101746_r14","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2011.11.048"},{"key":"S0022149X26101746_r5","unstructured":"Chartier, C , Ravinet, N , Bertocchi, M , Hirschauer, L , Waap, H and von Samson-Himmelstjerna, G (2019) Benzimidazole Resistance Survey in Gastrointestinal Nematodes of Dairy and Beef Cattle in Western France Using Egg Hatch Assay. In 27th Conference of the World Association for the Advancements of Veterinary Parasitology (WAAVP), Madison WI, USA, p. 228."},{"key":"S0022149X26101746_r3","doi-asserted-by":"publisher","DOI":"10.1186\/s13071-023-05756-7"},{"key":"S0022149X26101746_r16","first-page":"160","volume-title":"Manual of Veterinary Parasitological Techniques","year":"1986"},{"key":"S0022149X26101746_r21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1980.tb15983.x"},{"key":"S0022149X26101746_r20","first-page":"241","article-title":"Efficacy of ivermectin against gastrointestinal nematodes of cattle in Denmark evaluated by different methods for analysis of faecal egg count reduction","volume":"6","author":"Pe\u00f1a-Espinoza","year":"2016","journal-title":"International Journal for Parasitology: Drugs and Drug Resistance"},{"key":"S0022149X26101746_r18","doi-asserted-by":"publisher","DOI":"10.1136\/vr.100084"},{"key":"S0022149X26101746_r4","first-page":"1","article-title":"Biology and epidemiology of gastrointestinal nematodes in cattle","volume":"36","author":"Charlier","year":"2020","journal-title":"Veterinary Clinics: Food Animal Practice"},{"key":"S0022149X26101746_r7","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2017.067"},{"key":"S0022149X26101746_r8","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2008.10.030"},{"key":"S0022149X26101746_r9","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2022.109867"},{"key":"S0022149X26101746_r12","first-page":"17","article-title":"Biology, epidemiology, diagnosis, and management of anthelmintic resistance in gastrointestinal nematodes of livestock","volume":"36","author":"Kaplan","year":"2020","journal-title":"Veterinary Clinics: Food Animal Practice"},{"key":"S0022149X26101746_r23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2004.07.010"},{"key":"S0022149X26101746_r10","first-page":"163","article-title":"Anthelmintic resistance to ivermectin and moxidectin in gastrointestinal nematodes of cattle in Europe","volume":"5","author":"Geurden","year":"2015","journal-title":"International Journal for Parasitology: Drugs and Drug Resistance"},{"key":"S0022149X26101746_r13","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2023.109936"},{"key":"S0022149X26101746_r17","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetpar.2015.05.024"},{"key":"S0022149X26101746_r22","doi-asserted-by":"publisher","DOI":"10.1051\/parasite\/2020062"},{"key":"S0022149X26101746_r2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-019-06414-7"},{"key":"S0022149X26101746_r6","doi-asserted-by":"publisher","DOI":"10.1017\/S0022149X20000085"},{"key":"S0022149X26101746_r1","first-page":"129","article-title":"Limited efficacy of pour-on anthelmintic treatment of cattle under Swedish field conditions","volume":"3","author":"Areskog","year":"2013","journal-title":"International Journal for Parasitology: Drugs and Drug Resistance"},{"key":"S0022149X26101746_r15","doi-asserted-by":"publisher","DOI":"10.1186\/s13620-020-00167-x"},{"key":"S0022149X26101746_r19","doi-asserted-by":"publisher","DOI":"10.1186\/s13620-019-0142-8"}],"container-title":["Journal of Helminthology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022149X26101746","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T04:43:51Z","timestamp":1782449031000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022149X26101746\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":23,"alternative-id":["S0022149X26101746"],"URL":"https:\/\/doi.org\/10.1017\/s0022149x26101746","relation":{},"ISSN":["0022-149X","1475-2697"],"issn-type":[{"value":"0022-149X","type":"print"},{"value":"1475-2697","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"article-number":"e72"}}