{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:32:52Z","timestamp":1786350772472,"version":"build-2736575974"},"reference-count":47,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"unspecified","delay-in-days":221,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Helminthol."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In the current study, we used an immunotherapeutic approach in female\n                    <jats:italic>Swiss<\/jats:italic>\n                    albino mice inoculated intraperitoneally with viable protoscoleces. We investigated the potential immunomodulatory effect and protective properties of IL-17A at 125 pg\/mL on the development of secondary experimental echinococcosis.\n                    <jats:italic>Swiss<\/jats:italic>\n                    mice were inoculated intraperitoneally (i.p.) with 200 \u03bcL of a suspension containing 2000 viable protoscoleces to establish the infection model. IL-17A was administered intravenously two weeks after cystic echinococcosis (CE) induction. Cyst development and hepatic damage were macroscopically and histologically analysed. The hepatic expression of iNOS, TNF-\u03b1, NF-\u03baB, CD68, and vimentin was examined. We observed that in vivo IL-17A treatment at 125 pg\/mL reduced metacestode growth by 93.8%. Interestingly, treatment at this dose also led to decreased splenomegaly and improved liver tissue architecture. This was associated with a marked reduction in the fibrotic response, as evidenced by decreased collagen and reticulin fibre deposition. Moreover, IL-17A treatment resulted in reduced expression of key inflammatory and fibrotic markers, including iNOS, TNF-\u03b1, NF-\u03baB, CD68, and vimentin, in the liver parenchyma. Our findings highlight the antihydatid and immunoprotective effects of IL-17A and support its potential therapeutic role in managing CE.\n                  <\/jats:p>","DOI":"10.1017\/s0022149x26102090","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:25:48Z","timestamp":1786350348000},"source":"Crossref","is-referenced-by-count":0,"title":["Interleukin-17A: a novel player in the treatment of liver lesions associated with cystic echinococcosis"],"prefix":"10.1017","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-947X","authenticated-orcid":false,"given":"M.","family":"Labsi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02kb89c09","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sciences and Technology Houari 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