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Helminthol."],"published-print":{"date-parts":[[2026]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study was conducted to determine the\n                    <jats:italic>in vivo<\/jats:italic>\n                    anthelmintic efficacy and clinical safety of crude ethanolic extract (CEE) obtained from\n                    <jats:italic>Artemisia absinthium<\/jats:italic>\n                    in naturally infected Awassi breed sheep with gastrointestinal nematodes (GIN). A total of 18 non-pregnant sheep were divided into 3 groups of 6 animals each: CEE (1.0 g\/kg), albendazole (5 mg\/kg), and negative control (untreated). Changes in egg counts (EPG) were quantitatively monitored in faecal samples collected before treatment (day 0) and after treatment (days 7 and 15). The research findings showed that\n                    <jats:italic>A. absinthium<\/jats:italic>\n                    CEE significantly reduced the parasite load over time, with the highest efficacy achieved on day 15 (p &lt; 0.001), demonstrating statistically significant efficacy in suppressing the fecundity of GIN agents. According to the faecal egg count reduction test (FECRT), therapeutic success was observed in 76.77% of the CEE group and 100% of the albendazole group. The performance demonstrated by CEE confirmed the potential of plant secondary metabolites to reduce dependence on synthetic drugs, and the absence of any adverse effects during the trial period demonstrated the plant\u2019s high biosafety profile. Consequently,\n                    <jats:italic>A. absinthium<\/jats:italic>\n                    offers a powerful, economical, and residue-free biotherapeutic alternative to synthetic anthelmintics in sustainable and organic livestock models, countering global anthelmintic resistance. To the best of our knowledge, this study represents the first investigation in T\u00fcrkiye evaluating the anthelmintic efficacy of\n                    <jats:italic>A. absinthium<\/jats:italic>\n                    CEE in Awassi breed sheep naturally infected with GIN, providing the first regional efficacy data from \u015eanl\u0131urfa.\n                  <\/jats:p>","DOI":"10.1017\/s0022149x26102119","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T08:22:01Z","timestamp":1786350121000},"source":"Crossref","is-referenced-by-count":1,"title":["Comparison of\n                    <i>in vivo<\/i>\n                    anthelmintic efficacy of\n                    <i>Artemisia absinthium<\/i>\n                    extract and albendazole in Awassi breed sheep with natural gastrointestinal nematode 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