{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T02:12:39Z","timestamp":1671761559724},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":13771,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1971,9]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A single dose of inactivated louping-ill oil-adjuvant vaccine elicited a serologically detectable immune response in sheep lasting for at least 1 year. These sheep when exposed to a natural focus of louping-ill virus were completely protected from clinical disease and 1 year after vaccination were able to pass on a substantial maternal immunity to their lambs.<\/jats:p><jats:p>Twenty-nine per cent of unvaccinated sheep, exposed at the same time, died from clinical louping-ill; half of the survivors showed positive sero-conversion and became immune, while the other half remained susceptible. The incidence of fatal encephalomyelitis in sheep which were known to have circulated virus exceeded 50% in 2 out of 3 trials conducted simultaneously in different locations in Scotland in 1969.<\/jats:p>","DOI":"10.1017\/s0022172400021732","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T10:12:34Z","timestamp":1242382354000},"page":"479-489","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Field trials of an inactivated oil-adjuvant vaccine against louping-ill (Arbovirus group B)"],"prefix":"10.1017","volume":"69","author":[{"given":"J. G.","family":"Brotherston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. C.","family":"Bannatyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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B.","family":"Nicolson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400021732_ref012","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a070683"},{"key":"S0022172400021732_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400041097"},{"key":"S0022172400021732_ref007","first-page":"1","article-title":"The epizootiology of louping-ill and tick-borne fever with observations on the control of these diseases","author":"Gordon","year":"1962","journal-title":"Symposia of the Zoological Society of London"},{"key":"S0022172400021732_ref006","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700630103"},{"key":"S0022172400021732_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(71)90081-8"},{"key":"S0022172400021732_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(70)90068-X"},{"key":"S0022172400021732_ref002","doi-asserted-by":"publisher","DOI":"10.1136\/vr.84.20.514"},{"key":"S0022172400021732_ref001","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-185X.1958.tb01412.x"},{"key":"S0022172400021732_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400042170"},{"key":"S0022172400021732_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400039772"},{"key":"S0022172400021732_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(69)90078-4"},{"key":"S0022172400021732_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(71)90103-4"},{"key":"S0022172400021732_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0368-1742(32)80022-6"},{"key":"S0022172400021732_ref014","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400039139"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400021732","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T19:51:15Z","timestamp":1559332275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400021732\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1971,9]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1971,9]]}},"alternative-id":["S0022172400021732"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400021732","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1971,9]]},"assertion":[{"value":"Cambridge University Press 1971","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}