{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:02:38Z","timestamp":1758816158091},"reference-count":5,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":13589,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1972,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>In a comparative study of 24 different rubella virus strains, all but three formed small plaques in RK 13 cell cultures; of these one was the vaccine strain HPV-77, one was isolated from a congenitally infected infant, and the third was recovered from an adult who contracted severe rubella while handling this congenital strain. Whereas the plaque size of the vaccine strain was stable after further passage in cell culture, the plaque size of the other two rapidly diminished when the virus was passed in monkey kidney cells, and one of them was also reduced by passage in RK 13 cells. Cell culture passage of the typical small plaque strains did not result in altered plaque size.<\/jats:p>","DOI":"10.1017\/s0022172400022087","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T10:11:50Z","timestamp":1242382310000},"page":"49-53","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["An unusual plaque variant of rubella virus"],"prefix":"10.1017","volume":"70","author":[{"given":"Janine J.","family":"Gould","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwenneth D.","family":"Laurence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400022087_ref002","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1128\/JVI.3.2.157-163.1969","article-title":"Markers of rubella virus strains in RK 13 cell cultures","volume":"3","author":"Fogel","year":"1969","journal-title":"Journal of Virology"},{"key":"S0022172400022087_ref003","first-page":"195","article-title":"Antigenic structure of American and Japanese rubella virus strains and experimental vertical transmission of rubella virus in rabbits","volume":"11","author":"Kono","year":"1969","journal-title":"Symposium Series on Immunobiological Standardization"},{"key":"S0022172400022087_ref005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196609152751101"},{"key":"S0022172400022087_ref001","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-9-3-215"},{"key":"S0022172400022087_ref004","first-page":"249","article-title":"Morphology of rubella plaques in RK 13 cultures","volume":"11","author":"Lawrence","year":"1969","journal-title":"Symposium Series on Immunobiological Standardization"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400022087","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:14:23Z","timestamp":1589778863000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400022087\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,3]]},"references-count":5,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1972,3]]}},"alternative-id":["S0022172400022087"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400022087","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1972,3]]},"assertion":[{"value":"Cambridge University Press 1972","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}