{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:48:34Z","timestamp":1787496514073,"version":"build-2736575974"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":12887,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1974,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title>\n                  <jats:p>A large outbreak of streptococcal sore throat in a Royal Air Force Training Camp resulted in five cases of rheumatic fever among the 16- to 18-year-old apprentices, and one case in a 33-year-old airman. The most prevalent type of group A streptococcus isolated from throat swabs was M-type 5 and there was serological evidence that at least four of the rheumatic fever (R.F.) cases were due to this type.<\/jats:p>\n                  <jats:p>Among the patients with uncomplicated throat infection the anti-streptolysin O (ASO) and anti-deoxyribonuclease B (anti-DNAase B) responses were in general rather low, even where there was evidence of protective antibody against type 5. However, a combination of the results of the ASO and anti-DNAase B tests gave an estimate of the extent of streptococcal infection 15\u201325% higher than did either test alone.<\/jats:p>\n                  <jats:p>The titres of antibody to M-associated protein (MAP) were \u2265 60 in all the r.f. patients, and in about 50% of the other patients with ASO titres \u2265 200. This figure is unusually high compared with data from several other outbreaks of streptococcal infection due to different serotypes and also greatly exceeds comparable figures for cases of sporadic sore throat and acute glomerulonephritis.<\/jats:p>","DOI":"10.1017\/s0022172400023135","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T06:05:59Z","timestamp":1242367559000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["An outbreak of streptococcal sore throat and rheumatic fever in a Royal Air Force Training camp; significance of serum antibody to M-associated protein"],"prefix":"10.1017","volume":"72","author":[{"given":"Jean P.","family":"Widdowson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. R.","family":"Maxted","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W.","family":"Newrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Parkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400023135_ref010","doi-asserted-by":"publisher","DOI":"10.1084\/jem.78.2.127"},{"key":"S0022172400023135_ref008","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400046180"},{"key":"S0022172400023135_ref002","first-page":"173","article-title":"Antistreptolysin O: Its interaction with streptolysin O, its titration and a comparison of some standard preparations","volume":"25","author":"Gooder","year":"1961","journal-title":"Bulletin of the World Health Organisation"},{"key":"S0022172400023135_ref005","doi-asserted-by":"publisher","DOI":"10.1084\/jem.110.2.271"},{"key":"S0022172400023135_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400043308"},{"key":"S0022172400023135_ref011","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400021823"},{"key":"S0022172400023135_ref001","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1542\/peds.29.4.527","article-title":"Evaluation of the streptococcal desoxyribonuclease B and diphosphopyridine nucleotidase antibody tests in acute rheumatic fever and acute glomerulonephritis","volume":"39","author":"Ayoub","year":"1962","journal-title":"Pediatrics"},{"key":"S0022172400023135_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(48)91290-2"},{"key":"S0022172400023135_ref009","first-page":"867","article-title":"Streptococcal anti-deoxyribonuclease B: Microtechnique determination","volume":"71","author":"Nelson","year":"1968","journal-title":"The Journal of Laboratory and Clinical Medicine"},{"key":"S0022172400023135_ref007","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.6.3.224"},{"key":"S0022172400023135_ref003","unstructured":"Gooder H. & Williams R. E. O. (1961). Titration of antistreptolysin O. Association of Clinical Pathologists Broadsheet, no. 34 (New Series)."}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400023135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T07:30:42Z","timestamp":1739086242000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400023135\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,2]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1974,2]]}},"alternative-id":["S0022172400023135"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400023135","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1974,2]]},"assertion":[{"value":"Cambridge University Press 1974","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}