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Hyg."],"published-print":{"date-parts":[[1974,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Mice given an intraperitoneal injection of 0.5 mg.<jats:italic>Corynebacterium parvum<\/jats:italic>(dry weight) before vaccination with heat-killed (HK) or acetone-killed (AK)<jats:italic>Salmonella typhimurium<\/jats:italic>vaccine and later challenged intraperitoneally with<jats:italic>S. typhimurium<\/jats:italic>strain 1566, showed a statistically significant increase in mortality when compared with mice that had received only<jats:italic>C. parvum<\/jats:italic>but no vaccine. They also showed a higher mortality rate than mice receiving only HK or AK vaccine or mice that had received no vaccine before challenge. Prior administration of<jats:italic>C. parvum<\/jats:italic>to mice that are vaccinated with HK or AK vaccine appears to make them more susceptible to an intraperitoneal challenge with<jats:italic>S. typhimurium<\/jats:italic>. 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