{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T06:56:29Z","timestamp":1760079389411},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":12463,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1975,4]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The response to passive cutaneous anaphylaxis, dermal hypersensitivity and intravenous provocation tests has been compared in 30, 40, 31 and 24 cattle injected with foot-and-mouth disease vaccine 0, 1, 2 and 3 times respectively, using vaccine components and other substances as test materials. Reaginic antibodies, demonstrated by passive cutaneous anaphylaxis in goats, were directed against BHK 21 cell extracts (20), hydroxypropylmethylcellulose (3) and an unidentified vaccine component (3), and distributed in 0, 5, 19 and 75% of the cattle vaccinated 0, 1, 2 and 3 times. None of the animals showed clinical signs of allergy after vaccination. When BHK 21 cell extract was injected intradermally a significant correlation was noted between the development of large weals and the presence of reagins although the size of the weals was not correlated with the reagin titres. In the case of hydroxypropylmethylcellulose a similar trend was evident. The majority of cattle with large dermal weals possessed reagins but the number of reactions was too small for statistical evaluation. Dermal reactions to sodium penicillin, sodium carboxymethylcellulose, saponin and whole vaccine occurred in both unvaccinated and vaccinated cattle but BHK 21 cell lysate and normal bovine serum provoked weals which increased in frequency according to the number of vaccinations experienced. Intravenous hydroxypropylmethylcellulose elicited a response in all the animals previously injected with certain batches of vaccine but none in those injected with other batches or in unvaccinated controls. BHK 21 cell extract intravenously produced a clinical response in half the tested animals which was uncorrelated with the results of the passive cutaneous anaphylaxis or dermal hypersensitivity tests.<\/jats:p>","DOI":"10.1017\/s0022172400024232","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T05:57:52Z","timestamp":1242367072000},"page":"169-181","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["The evaluation of hypersensitivity tests in cattle after foot-and-mouth disease vaccination"],"prefix":"10.1017","volume":"74","author":[{"given":"L.","family":"Black","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. W. F.","family":"Pay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400024232_ref050","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90615-0"},{"key":"S0022172400024232_ref046","volume-title":"European Commission for the Control of Foot-and-Mouth Disease","author":"Ubertini","year":"1970"},{"key":"S0022172400024232_ref041","first-page":"757","article-title":"Investigaciones realizadas con los virus atenuados de la fiebre aftosa de los tipos 'O' y 'A' Vallee en Venezuela","volume":"61","author":"Palacios","year":"1964","journal-title":"Bulletin de l'office International des Epizooties"},{"key":"S0022172400024232_ref036","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5708.501"},{"key":"S0022172400024232_ref047","first-page":"366","article-title":"Anti foot-and-mouth disease vaccination and immediate anaphylactic reactions","volume":"21","author":"Ubertini","year":"1970","journal-title":"Veterinaria Italiana"},{"key":"S0022172400024232_ref035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1969.tb00132.x"},{"key":"S0022172400024232_ref034","first-page":"182","article-title":"Antibiotikallergien beim Tier","volume":"82","author":"Mayr","year":"1969","journal-title":"Berliner und M\u00fcnchener tierz\u00e4rztliche Wochenschrift"},{"key":"S0022172400024232_ref042","first-page":"27","volume-title":"In Frontiers of Biology. 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Abt. 1, Orig."},{"key":"S0022172400024232_ref026","doi-asserted-by":"publisher","DOI":"10.1016\/0021-8707(61)90068-5"},{"key":"S0022172400024232_ref027","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1971.03180200030006"},{"key":"S0022172400024232_ref022","first-page":"162","article-title":"Contributo allo studio delle reazione anafilattiche precoci nella vaccinazione antiafosa dei bovine","volume":"4","author":"Ginanni","year":"1972","journal-title":"Atti Societa Italiana Buiatria"},{"key":"S0022172400024232_ref040","article-title":"Clinical, morphological and experimental studies of laminitis in cattle","volume":"4","author":"Nilsson","year":"1963","journal-title":"Acta Veterinaria Scandinavica"},{"key":"S0022172400024232_ref003","first-page":"308","article-title":"Crisis anafilactica producida por vacuna anti-aftosa II. 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G . & Pay T. W. F . (1975). Immediate type hypersensitivity in cattle produced by foot-and-mouth disease vaccines. Demonstration of reaginic antibody. Research in Veterinary Science (in the Press)."},{"key":"S0022172400024232_ref023","first-page":"497","article-title":"Provocative nasal tests for diagnosis of inhalent allergens: correlation with skin tests and clinical symptoms","volume":"23","author":"Hosen","year":"1965","journal-title":"Annals of Allergy"},{"key":"S0022172400024232_ref006","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0450.1971.tb00360.x"},{"key":"S0022172400024232_ref009","first-page":"117","article-title":"The influence of serum IgE levels of selected recipients, including patients with allergy, helminthiasis and tuberculosis, on the apparent P-K titre of a reaginic serum","volume":"14","author":"Bazarel","year":"1973","journal-title":"Clinical and Experimental Immunology"},{"key":"S0022172400024232_ref014","volume-title":"Response to hydroxypropyl-methylcelullose","author":"Black"},{"key":"S0022172400024232_ref016","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1152\/ajplegacy.1939.127.1.71","article-title":"The blood histamine during anaphylactic shock in the horse and calf","volume":"127","author":"Code","year":"1939","journal-title":"American Journal of Physiology"},{"key":"S0022172400024232_ref015","volume-title":"European Commission for the Control of Foot-and-Mouth Disease","author":"Capstick","year":"1970"},{"key":"S0022172400024232_ref024","first-page":"648","article-title":"Hypersensitivity in guinea pigs induced by foot-and-mouth disease vaccine and vaccine components","volume":"21","author":"Jensen","year":"1969","journal-title":"Nordisk Veterinaermedicin"},{"key":"S0022172400024232_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(71)90008-X"},{"key":"S0022172400024232_ref031","first-page":"31","article-title":"Complications of vaccinating cattle against Foot-and-Mouth disease","volume":"43","author":"Makarova","year":"1966","journal-title":"Veterinariya, Moscow"},{"key":"S0022172400024232_ref012","doi-asserted-by":"publisher","DOI":"10.1159\/000230461"},{"key":"S0022172400024232_ref038","volume-title":"Third Inter-American Meeting on FMD and Zoonosis Control, Buenos Aires","author":"Mussgay","year":"1970"},{"key":"S0022172400024232_ref010","unstructured":"Beadle G. G . (1971). Allergy problems with foot-and-mouth disease vaccine. M.V.Sc. 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