{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:14:53Z","timestamp":1761894893088},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":14228,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1970,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The relationship between the serological findings for brucellosis and the epidemiological factors has been studied in veterinary surgeons in Northern Ireland. The anti-human globulin (Coombs) test and the complement-fixation test for brucella were used in two groups of veterinary surgeons, those self-employed and those employed by the Ministry of Agriculture.<\/jats:p><jats:p>Significant serological differences were found to exist between the two groups. Those in private practice showed changes related to age, cattle skin rash, reactions to S. 19 vaccine accidents and symptoms suggestive of brucellosis in the past or the last year. But those working for the Ministry only showed titre changes related to the length of their private practice experience before joining the Ministry. In neither group was there a relationship between serological findings and the type of milk drunk or any particular group of symptoms suggestive of brucellosis.<\/jats:p><jats:p>The findings indicate that high titres to brucella by the Coombs and complement-fixation test can occur in people repeatedly exposed to infection at work. Titres which would be of diagnostic importance in the rest of the population may be of little diagnostic significance even when they are as high as 160 Coombs and 128 complement fixation.<\/jats:p>","DOI":"10.1017\/s0022172400028655","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T10:16:43Z","timestamp":1242382603000},"page":"173-187","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["The relevance of the anti-human globulin (Coombs) test and the complement-fixation test in the diagnosis of brucellosis"],"prefix":"10.1017","volume":"68","author":[{"given":"D. G.","family":"McDevitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400028655_ref009","first-page":"602","article-title":"Chronic brucellosis in the practising veterinary surgeon","volume":"79","author":"Kerr","year":"1966","journal-title":"Veterinary Record"},{"key":"S0022172400028655_ref002","first-page":"96","article-title":"Technique of complement fixation test applicable to the diagnosis of virus diseases","volume":"21","author":"Bradstreet","year":"1962","journal-title":"Monthly Bulletin of the Ministry of Health and Public Health Laboratory Service"},{"key":"S0022172400028655_ref013","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400041826"},{"key":"S0022172400028655_ref015","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196506172722403"},{"key":"S0022172400028655_ref011","first-page":"952","article-title":"Brucellosis among veterinary surgeons","volume":"ii","year":"1966","journal-title":"Lancet"},{"key":"S0022172400028655_ref004","volume-title":"Brucella Infection and Undulant Fever in Man","author":"Dalrymple-Champneys","year":"1960"},{"key":"S0022172400028655_ref017","volume-title":"The Nature of Brucellosis","author":"Spink","year":"1956"},{"key":"S0022172400028655_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90192-4"},{"key":"S0022172400028655_ref019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(51)91875-2"},{"key":"S0022172400028655_ref016","doi-asserted-by":"crossref","first-page":"358","DOI":"10.7326\/0003-4819-35-2-358","article-title":"What is chronic brucellosis?","volume":"35","author":"Spink","year":"1951","journal-title":"Annals of Internal Medicine"},{"key":"S0022172400028655_ref010","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(66)90492-2"},{"key":"S0022172400028655_ref018","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1952.02930260007003"},{"key":"S0022172400028655_ref008","unstructured":"Joint FAO\/WHO Expert Committee on Brucellosis (1964). 4th Report. Technical Report Series, World Health Organization, no. 289."},{"key":"S0022172400028655_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)92914-5"},{"key":"S0022172400028655_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/4582639"},{"key":"S0022172400028655_ref003","article-title":"Undulant fever with special reference to animal sources of infection and the possibility of its prevalence in England and Wales","author":"Dalrymple-Champneys","year":"1929","journal-title":"Reports on Public Health and Medical Subjects, Ministry of Health"},{"key":"S0022172400028655_ref007","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4049\/jimmunol.91.1.11","article-title":"Studies on the immune globulins of human serum. II. A study of the distribution of anti-brucella and anti-diphtheria antibody activities among gamma-SS, gamma-IM and gamma-IA globulin fractions","volume":"91","author":"Heremans","year":"1963","journal-title":"Journal of Immunology"},{"key":"S0022172400028655_ref012","unstructured":"McDevitt D. G. (1968). Studies in Human Brucellosis. M.D. Thesis, Queen's University, Belfast."},{"key":"S0022172400028655_ref001","first-page":"95","article-title":"Brucella abortus agglutinins in the sera of pregnant women and blood donors","volume":"17","author":"Bartram","year":"1963","journal-title":"British Journal of Preventive and Social Medicine"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400028655","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T11:14:13Z","timestamp":1710328453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400028655\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,6]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1970,6]]}},"alternative-id":["S0022172400028655"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400028655","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1970,6]]},"assertion":[{"value":"Cambridge University Press 1970","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}