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Hyg."],"published-print":{"date-parts":[[1957,9]]},"abstract":"<jats:p>Mice surviving infection with a strain of<jats:italic>Salm. typhimurium<\/jats:italic>of reduced virulence developed a progressive resistance to reinfection with virulent strains.<\/jats:p><jats:p>The degree of resistance was greater than that of vaccinated mice, although the primary infection had not caused any significant degree of natural selection or higher serum titres of O antibody.<\/jats:p><jats:p>The previously infected animals responded to reinfection with a virulent strain of<jats:italic>Salm. typhimurium<\/jats:italic>by gradually restraining bacterial growth. Many of the survivors eradicated the reinfecting strain.<\/jats:p><jats:p>The possible reasons for the difference between vaccinated mice and survivors of previous infection have been discussed.<\/jats:p><jats:p>I am indebted to the Medical Research Council for the provision of a grant towards the expenses of this investigation and to Mr T. 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