{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T22:30:36Z","timestamp":1698013836653},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":17880,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1960,6]]},"abstract":"<jats:p>1. The average lethal dose of fluoracetamide for wild <jats:italic>R. norvegicus<\/jats:italic> was found to be 13 mg.\/kg. of body weight and the LD<jats:sub>95<\/jats:sub>, about 43 mg.\/kg.<\/jats:p><jats:p>2. Wild rats offered bait contatining 0\u00b75, 1 and 2% fluoracetamide, after a period of conditioning, seemed to find it palatable and, on the average, ingested the equivalent of 18\u2013100 LD<jats:sub>50<\/jats:sub>'s. Warning symptoms appeared in about an hour or longer and included short convulsive spasms.<\/jats:p><jats:p>3. The speed of onset of warning symptoms leading to cessation of feeding was studied in albino rats dosed with the equivalent of 2 LD<jats:sub>50<\/jats:sub>'s of sodium fluoracetate, zinc phosphide or fluoracetamide. Feeding ceased soonest in the case of sodium fluroacetate. Zinc phosphide gave very variable results, but it is thought that if wild rats had been used, feeding would have stopped nearly as soon as with sodium fluoracetate.<\/jats:p><jats:p>4. It is considered that field trials to compare the efficiency of 1% flouracetamide and 2\u00b75% zinc phosphide, both with \u2018prebaiting\u2019, would be well justified.<\/jats:p><jats:p>5. Fluoracetamide at 2% may also prove to be a good alternative to 0\u00b725% sodium fluoracetate as a \u2018direct\u2019 poison for controlling rats in sewers.<\/jats:p><jats:p>We are indebted to Miss Y. Larthe and Miss E. J. Taylor who took part in the bioassay and in one of the experiments with the marked rats.<\/jats:p>","DOI":"10.1017\/s0022172400038201","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T06:30:52Z","timestamp":1242369052000},"page":"125-132","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Some properties of fluoracetamide as a rodenticide"],"prefix":"10.1017","volume":"58","author":[{"given":"E. W.","family":"Bentley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400038201_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400014996"},{"key":"S0022172400038201_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(56)92412-6"},{"key":"S0022172400038201_ref005","doi-asserted-by":"publisher","DOI":"10.2307\/4585662"},{"key":"S0022172400038201_ref006","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-62-15358"},{"key":"S0022172400038201_ref009","volume-title":"Rat-borne Disease. Prevention and Control","year":"1949"},{"key":"S0022172400038201_ref003","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.2740060410"},{"key":"S0022172400038201_ref007","first-page":"427","article-title":"Studies on flourine compounds. II. Toxicology of higher alkyl flouracetates","volume":"56","author":"Gitter","year":"1953","journal-title":"Proc. Acad. Sci. Amst."},{"key":"S0022172400038201_ref001","volume-title":"M.A.F.F. Tech. Bull.","author":"Bentley","year":"1958"},{"key":"S0022172400038201_ref004","volume-title":"Control of Rats and Mice.","author":"Chitty","year":"1954"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400038201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T15:33:56Z","timestamp":1559748836000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400038201\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1960,6]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1960,6]]}},"alternative-id":["S0022172400038201"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400038201","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1960,6]]},"assertion":[{"value":"Cambridge University Press 1960","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}