{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T04:23:31Z","timestamp":1649046211740},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":14410,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["Epidemiol. Infect."],"published-print":{"date-parts":[[1969,12]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>The vaccination of sheep with one dose of the monkey-and mouse-attenuated tick-borne encephalitis virus (the Hy-HK 28 \u20182\u2019 clone) causes seroconversion from negative into positive in 85% of animals. In sheep with pre-existing virus-neutralizing antibodies and increas of their titres was observed in 81%. The antibodies persisted for at least 12 months after the vaccination and during the summer period of grazing the number of serologically positive animals even increased.<\/jats:p><jats:p>The vaccinated animals, in contrast to the non-immune control sheep, developed no viraemia after challenge with the virulent louping-ill virus, performed 11 months after immunization.<\/jats:p>","DOI":"10.1017\/s0022172400042170","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T10:18:19Z","timestamp":1242382699000},"page":"731-738","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["The serological response and long-lasting resistance against infection with louping-ill virus in sheep immunized with a highly attenuated tick-borne encephalitis virus"],"prefix":"10.1017","volume":"67","author":[{"given":"V.","family":"Mayer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Bla\u0161kovi\u010d","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Ernek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lib\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400042170_ref011","doi-asserted-by":"publisher","DOI":"10.1038\/178581a0"},{"key":"S0022172400042170_ref009","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400045113"},{"key":"S0022172400042170_ref008","first-page":"334","article-title":"Study of the virulence of the tick-borne encephalitis virus. VII. Immunogenicity of attenuated virus (clone Hy-HK28 \u20182\u2019) for goats, cattle and sheep","volume":"11","author":"Mayer","year":"1967","journal-title":"Acta virot., Prague"},{"key":"S0022172400042170_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400039139"},{"key":"S0022172400042170_ref007","first-page":"407","article-title":"Study of the virulence of the tick-borne encephalitis virus. VIII. Differentiation by chromatography on hydroxylapatite of clones possessing distinct biological properties","volume":"11","author":"Mayer","year":"1967","journal-title":"Acta virol., Prague"},{"key":"S0022172400042170_ref004","first-page":"501","article-title":"A mutant of tick-borne encephalitis (TE) virus with lost neurovirulence for monkeys","volume":"10","author":"Mayer","year":"1966","journal-title":"Acta virol., Prague"},{"key":"S0022172400042170_ref005","first-page":"321","article-title":"Study of the virulence of the tick-borne encephalitis virus. VI. Intracerebral infection of monkeys with clones of experimentally attenuated virus","volume":"11","author":"Mayer","year":"1967","journal-title":"Acta virol., Prague"},{"key":"S0022172400042170_ref010","first-page":"3","article-title":"Isolation of new strains of meningoencephalitis virus in the Brno region in the summer of 1953","volume":"9","author":"Posp\u00ed\u0161il","year":"1954","journal-title":"L\u00e9k\u00e1r. Listy"},{"key":"S0022172400042170_ref003","first-page":"516","article-title":"Assay of the tick-borne encephalitis virus in HeLa cells. III. Selection and properties of virus antigen for an in vitro neutralization test","volume":"7","author":"Lib\u00edkov\u00e1","year":"1963","journal-title":"Acta virol., Prague"},{"key":"S0022172400042170_ref006","first-page":"403","article-title":"Study of the virulence of the tick-borne encephalitis virus. IX. Intranasal infection of monkeys with genetically defined clones","volume":"12","author":"Mayer","year":"1968","journal-title":"Acta virot., Prague"},{"key":"S0022172400042170_ref002","first-page":"368","article-title":"Methods for investigating immunization against louping-ill","volume":"27","author":"Edward","year":"1947","journal-title":"Br. J. exp. Path."},{"key":"S0022172400042170_ref001","article-title":"Immunization of domestic milk-giving animals with the live attenuated tick-borne encephalitis virus. Experimental study","volume":"15","author":"Bla\u010dkovi\u010d","year":"1969","journal-title":"Biologick\u00e9 pr\u00e1ce"}],"container-title":["Epidemiology and Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400042170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T19:41:23Z","timestamp":1559418083000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400042170\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1969,12]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1969,12]]}},"alternative-id":["S0022172400042170"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400042170","relation":{},"ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":[],"published":{"date-parts":[[1969,12]]},"assertion":[{"value":"Cambridge University Press 1969","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}