{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T13:10:03Z","timestamp":1739106603248,"version":"3.37.0"},"reference-count":9,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":12584,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1974,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>An analysis was made of the dose-response of several populations of<jats:italic>Rattus norvegicus<\/jats:italic>fed upon baits containing 0\u00b7005% warfarin for various numbers of days. Warfarin-susceptible populations fell within a narrow range, with LFP50s and LFP98s (lethal feeding periods in days to obtain 50% and 98% mortalities respectively) of up to 3\u00b70 and 5\u00b70 days respectively. The probability of an individual rat from these populations surviving a six-day feeding period was estimated at 0\u00b7003 or less. Populations with responses falling beyond these limits were regarded as warfarin-resistant.<\/jats:p><jats:p>Six of nine populations of<jats:italic>R. norvegicus<\/jats:italic>, from England, Germany and the United States, were determined to be warfarin-susceptible within the narrow limits given above. In all six cases, no animals survived the six-day WHO feeding test for anticoagulant susceptibility. In three populations from the United States, where rats survived six days feeding, their population responses clearly fell outside the measures given above. It is suggested, tentatively, that anticoagulantresistant Norway rat populations be defined as those whose LFP50 and LFP98 exceeds 3\u00b70 and 5\u00b70 days respectively, and in which the probability of an individual animal surviving a six-day feeding upon 0\u00b7005% warfarin is 0\u00b701 or more.<\/jats:p>","DOI":"10.1017\/s0022172400042753","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:59:36Z","timestamp":1242381576000},"page":"401-407","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["An analysis of the susceptibilities of several populations of<i>Rattus norvegicus<\/i>to warfarin"],"prefix":"10.1017","volume":"73","author":[{"given":"Joe E.","family":"Brooks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan M.","family":"Bowerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400042753_ref004","first-page":"303","article-title":"Laboratory investigation of resistance to warfarin of Rattus norvegicus Berk. in Montgomeryshire and Shropshire","volume":"61","author":"Drummond","year":"1968","journal-title":"Annals of Applied Biology"},{"key":"S0022172400042753_ref002","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400022683"},{"key":"S0022172400042753_ref001","first-page":"19","article-title":"The warfarin resistance problem in England and Wales","volume":"32","author":"Bentley","year":"1969","journal-title":"Schriftenreihe des Vereins f\u00fcr Wasser., Boden- und Lufthygiene"},{"key":"S0022172400042753_ref003","first-page":"139","article-title":"Tentative instructions for determining the susceptibility of rodents to anticoagulant rodenticides","volume":"66.217","author":"Drummond","year":"1966","journal-title":"World Health Organization, Seminar on Rodents and Rodent Ectoparasites"},{"key":"S0022172400042753_ref006","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0022-3565(25)03549-9","article-title":"A simplified method of evaluating dose\u2013effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"S0022172400042753_ref005","first-page":"56","article-title":"Anticoagulant resistance in Norway rats in U.S. cities","volume":"41","author":"Jackson","year":"1973","journal-title":"Pest Control"},{"key":"S0022172400042753_ref007","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400040109"},{"key":"S0022172400042753_ref008","unstructured":"Telle H. J. (1971). Resistance to warfarin of the Brown rat (R. norvegicus) in Germany. World Health Organization, VBC\/71.331, 5 pp. (Unpublished working paper.)"},{"key":"S0022172400042753_ref009","unstructured":"World Health Organization (1970). Provisional instructions for determining the susceptibility of rodents to anticoagulant rodenticides. World Health Organization, Technical Report Series, no. 443, pp. 140\u20137."}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400042753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T12:30:32Z","timestamp":1739104232000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400042753\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,12]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1974,12]]}},"alternative-id":["S0022172400042753"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400042753","relation":{},"ISSN":["0022-1724"],"issn-type":[{"type":"print","value":"0022-1724"}],"subject":[],"published":{"date-parts":[[1974,12]]},"assertion":[{"value":"Cambridge University Press 1974","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}