{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T20:11:29Z","timestamp":1669666289887},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":13224,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1973,3]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Serological investigations were carried out on 147 patients with Paul\u2014Bunnell positive infectious mononucleosis (IM) from the general population. All possessed antibody to the Epstein\u2014Barr virus (EBV) and 63% showed serological evidence of recent infection. Contacts of 132 patients, 306 in all, were followed serologically; within 6 months of the index cases' illness twenty one contacts developed evidence of EBV infection or re-infection and of these five developed overt IM. The secondary attack rate of EBV infection among susceptible contacts was at least 19%; the corresponding figure for clinically apparent IM was 6%. EBY antibody prevalence among patients' siblings was significantly lower than among age-matched controls, suggesting that cases of IM come from families with a lower than normal previous experience of the virus. Of thirteen patients with persistently Paul\u2014Bunnell negative \u2018glandular fever\u2019 four had serological evidence of recent EBV infection and two had probable cytomegalovirus mononucleosis. Recent EBV infection may have been associated with the illnesses of five of the remaining patients.<\/jats:p>","DOI":"10.1017\/s0022172400046325","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T10:09:28Z","timestamp":1242382168000},"page":"151-161","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Epstein-Barr virus antibody in cases and contacts of infectious mononucleosis; a family study"],"prefix":"10.1017","volume":"71","author":[{"given":"F. J.","family":"Nye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. P.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400046325_ref020","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(72)90229-2"},{"key":"S0022172400046325_ref010","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.59.1.94"},{"key":"S0022172400046325_ref002","volume-title":"Clinical Diagnosis by Laboratory Methods","author":"Davidsohn","year":"1968"},{"key":"S0022172400046325_ref019","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5682.526"},{"key":"S0022172400046325_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/121.3.303"},{"key":"S0022172400046325_ref023","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400044983"},{"key":"S0022172400046325_ref011","first-page":"1147","article-title":"Antibodies to Epstein\u2014Barr virus in Burkitt's lymphoma and control groups","volume":"43","author":"Henle","year":"1969","journal-title":"Journal of the National Cancer Institute"},{"key":"S0022172400046325_ref007","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/124.4.422"},{"key":"S0022172400046325_ref005","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196811212792101"},{"key":"S0022172400046325_ref017","first-page":"361","article-title":"Prevalence, incidence, and persistence of EB virus antibody in young adults","volume":"282","author":"Niederman","year":"1970","journal-title":"American Journal of Medicine"},{"key":"S0022172400046325_ref018","doi-asserted-by":"publisher","DOI":"10.1038\/231047a0"},{"key":"S0022172400046325_ref016","first-page":"139","article-title":"Infectious Mononucleosis. Clinical manifestations in relation to EB virus antibodies","volume":"203","author":"Niederman","year":"1968","journal-title":"Journal of the American Medical Association"},{"key":"S0022172400046325_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60169-4"},{"key":"S0022172400046325_ref012","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90182-X"},{"key":"S0022172400046325_ref025","first-page":"643","article-title":"Infectious mononucleosis and its relationship to EB virus antibody","volume":"iv","year":"1971","journal-title":"British Medical Journal"},{"key":"S0022172400046325_ref015","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/49.1.3"},{"key":"S0022172400046325_ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(71)91937-4"},{"key":"S0022172400046325_ref001","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.10.3.243"},{"key":"S0022172400046325_ref014","first-page":"1260","article-title":"Serological response of the EBV antibodies in pediatric cases of infectious mononucleosis and in their contacts","volume":"102","author":"Joncas","year":"1970","journal-title":"Canadian Medical Association Journal"},{"key":"S0022172400046325_ref024","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196703092761006"},{"key":"S0022172400046325_ref022","doi-asserted-by":"publisher","DOI":"10.1126\/science.108.2815.660"},{"key":"S0022172400046325_ref003","volume-title":"Infectious Mononucleosis","author":"Davidsohn","year":"1969"},{"key":"S0022172400046325_ref008","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1128\/JB.91.3.1248-1256.1966","article-title":"Immunofluorescence in cells derived from Burkitt's lymphoma","volume":"91","author":"Henle","year":"1966","journal-title":"Journal of Bacteriology"},{"key":"S0022172400046325_ref021","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1969.03160090035008"},{"key":"S0022172400046325_ref026","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-133-34598"},{"key":"S0022172400046325_ref013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197009032831002"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400046325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:14:19Z","timestamp":1589778859000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400046325\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,3]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1973,3]]}},"alternative-id":["S0022172400046325"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400046325","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1973,3]]},"assertion":[{"value":"Copyright \u00a9 Cambridge University Press 1973","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}