{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T20:06:18Z","timestamp":1697832378212},"reference-count":17,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":12522,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1975,2]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>A serological analysis of mycelial antigens of<jats:italic>Thermoactinomyces vulgaris<\/jats:italic>in immunodiffusion with human sera revealed five individual antigens. Three antigens were proteins, sensitive to pronase and soluble in phenol. Two were cationic polysaccharides, sensitive to sodium periodate, and containing glucosamine and muramic acid.<\/jats:p><jats:p>Latex coated with mycelial antigens was compared with precipitin tests in detecting antibodies to<jats:italic>T. vulgaris;<\/jats:italic>the number of positive results detected by each test differed slightly, and a combination of the two tests detected the highest number. Counterimmunoelectrophoresis (CIE) was shown to be a very sensitive method for detecting precipitins, but not for their measurement. A prospective evaluation of immunodiffusion, latex agglutination and CIE as potential serodiagnostic techniques for farmer's lung disease is suggested.<\/jats:p>","DOI":"10.1017\/s0022172400046696","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:58:06Z","timestamp":1242381486000},"page":"35-41","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Antibody responses in patients with farmer's lung disease to antigens from<i>Thermoactinomyces vulgaris<\/i>"],"prefix":"10.1017","volume":"74","author":[{"given":"M. R.","family":"Hollingdale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400046696_ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(71)90069-8"},{"key":"S0022172400046696_ref010","first-page":"96","article-title":"The latex agglutination test in farmer's lung","volume":"26","author":"Murray","year":"1967","journal-title":"Monthly Bulletin of the Ministry of Health and the Public Health Laboratory Service"},{"key":"S0022172400046696_ref006","first-page":"777","article-title":"Farmer's lung in an adolescent boy","volume":"118","author":"Hughes","year":"1969","journal-title":"American Journal of Diseases of Children"},{"key":"S0022172400046696_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S002217240002324X"},{"key":"S0022172400046696_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400046350"},{"key":"S0022172400046696_ref017","first-page":"393","article-title":"Hypersensitivity pneumonitis: experimental production in guinea pigs with antigens of Micropolyspora faeni","volume":"39","author":"Wilkie","year":"1973","journal-title":"Pathologia et Microbiologia"},{"key":"S0022172400046696_ref016","first-page":"652","article-title":"Pneumonitis due to Micromonospora vulgaris (farmer's lung)","volume":"95","author":"Wenzel","year":"1967","journal-title":"American Review of Respiratory Diseases"},{"key":"S0022172400046696_ref004","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400042303"},{"key":"S0022172400046696_ref012","doi-asserted-by":"publisher","DOI":"10.1136\/thx.20.1.21"},{"key":"S0022172400046696_ref007","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(71)80386-1"},{"key":"S0022172400046696_ref009","first-page":"511","article-title":"Cell-mediated immunity in experimental hypersensitivity pneumonitis","volume":"20","author":"Kawai","year":"1972","journal-title":"Clinical Research"},{"key":"S0022172400046696_ref001","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1128\/AEM.13.2.236-243.1965","article-title":"Chemical composition of cell-wall preparations from strains of various form-genera of aerobic actinomycetes","volume":"13","author":"Becker","year":"1965","journal-title":"Applied Microbiology"},{"key":"S0022172400046696_ref013","first-page":"106","article-title":"Demonstration of precipitins against extracts of thermophilic actinomyces in the sera of affected individuals","volume":"39","author":"Salvaggio","year":"1967","journal-title":"Journal of Allergy"},{"key":"S0022172400046696_ref008","first-page":"526","volume-title":"Experimental Immunochemistry","author":"Kabat","year":"1961"},{"key":"S0022172400046696_ref002","first-page":"770","article-title":"Detection of type-specific pneumococcal antigens by counterimmunoelectrophoresis. 1. Methodology and immunologic properties of pneumococcal antigens","volume":"81","author":"Coonrod","year":"1973","journal-title":"Journal of Laboratory and Clinical Medicine"},{"key":"S0022172400046696_ref011","volume-title":"Monographs in Allergy","author":"Pepys","year":"1969"},{"key":"S0022172400046696_ref014","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(73)90021-3"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400046696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:13:08Z","timestamp":1589778788000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400046696\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,2]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,2]]}},"alternative-id":["S0022172400046696"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400046696","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1975,2]]},"assertion":[{"value":"Cambridge University Press 1975","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}