{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:14:42Z","timestamp":1758845682814},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":12341,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1975,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Groups of patients with lepromatous and tuberculoid leprosy and hospital staff from six leprosaria in East Africa and \u2018non-contact\u2019 groups of villagers or staff from general hospitals have been skin tested with 10 reagents. These were prepared by ultrasonic disintegration from<jats:italic>M. tuberculosis, M. duvalii, M. chelonei<\/jats:italic>and 7 other species identified in the Ugandan environment. Comparisons were made of the percentages of positive reactors in each study group for each reagent. The \u2018specific\u2019 defect of lepromatous patients was found to apply to a variable extent to six of the species tested, but not to<jats:italic>M. tuberculosis, M. avium<\/jats:italic>or<jats:italic>M. \u2018A<\/jats:italic>*\u2019. The defect applied most noticeably to<jats:italic>M. nonchromogenicum<\/jats:italic>and<jats:italic>M. vaccae<\/jats:italic>, suggesting that they are more closely related to<jats:italic>M. leprae<\/jats:italic>than are the other species tested. The reagent Chelonin produced unexpected and anomalous results in the lepromatous group. It is suggested that this was due to an unusually slow clearing of Arthus' reaction.<\/jats:p>","DOI":"10.1017\/s0022172400047069","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:56:13Z","timestamp":1242381373000},"page":"57-68","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":37,"title":["Multiple skin testing in leprosy"],"prefix":"10.1017","volume":"75","author":[{"given":"R. C.","family":"Paul","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. L.","family":"Stanford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Carswell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S0022172400047069_ref012","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400046659"},{"key":"S0022172400047069_ref010","first-page":"374","article-title":"A preliminary study of delayed hypersensitivity to Mycobacterium chelonei, M. fortuitum (ranae) and M. gordonae in cattle from two areas in Uganda","volume":"55","author":"Pritchard","year":"1974","journal-title":"British Journal of Experimental Pathology"},{"key":"S0022172400047069_ref009","doi-asserted-by":"publisher","DOI":"10.5935\/0305-7518.19730002"},{"key":"S0022172400047069_ref005","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5880.557"},{"key":"S0022172400047069_ref004","first-page":"273","article-title":"Recent advances in the immunology of leprosy with special reference to new approaches in immunoprophylaxis","volume":"72","author":"Godal","year":"1974","journal-title":"Bulletin de l'institut Pasteur"},{"key":"S0022172400047069_ref011","first-page":"389","article-title":"A preliminary report on some studies of environmental mycobacteria from Uganda","volume":"53","author":"Stanford","year":"1973","journal-title":"Annales de la Soci\u00e9t\u00e9 beige de M\u00e9decine tropicale."},{"key":"S0022172400047069_ref006","first-page":"7","article-title":"B.C.G. vaccination of children against leprosy: First results of a trial in Uganda","volume":"i","author":"Kinnear","year":"1966","journal-title":"British Medical Journal"},{"key":"S0022172400047069_ref002","first-page":"133","article-title":"Beschreiburg der neuen Species Mycobacterium vaccae n. sp. 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Medicine and Biology (Tokyo)"},{"key":"S0022172400047069_ref003","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196802082780603"},{"key":"S0022172400047069_ref007","first-page":"31","article-title":"Mycobact\u00e9ries \u00e0 pigment rose","volume":"122","author":"Korsak","year":"1972","journal-title":"Annals de l'institut Pasteur"},{"key":"S0022172400047069_ref008","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"Journal of Biological Chemistry"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400047069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T13:02:01Z","timestamp":1633438921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400047069\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,8]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,8]]}},"alternative-id":["S0022172400047069"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400047069","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1975,8]]},"assertion":[{"value":"Cambridge University Press 1975","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}