{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T13:43:20Z","timestamp":1791380600146,"version":"4.3.3"},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":12341,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1975,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Intravenous provocation (IVP) tests demonstrated that hydroxypropylmethylcellulose (MC) was able to elicit anaphylactic signs in cattle vaccinated with foot-and-mouth disease (FMD) vaccine produced at one centre but not with similar vaccine produced at another. The former vaccine also provoked serum reagins which were demonstrated by passive cutaneous anaphylaxis (PCA) tests in goats.<\/jats:p><jats:p>Reaginic sera which reacted specifically with MC were used in PCA tests to screen samples taken serially from the vaccine production lines. The reactions observed suggested that a substance with MC or similar specificity was present in the antifoaming agent routinely added to vaccines.<\/jats:p>","DOI":"10.1017\/s0022172400047082","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T05:56:13Z","timestamp":1242366973000},"page":"79-86","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":7,"title":["Hypersensitivity in cattle after foot -and -mouth disease vaccination: response to hydroxypropylmethylcellulose"],"prefix":"10.1017","volume":"75","author":[{"given":"L.","family":"Black","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. J. R. R.","family":"Menard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. G.","family":"Beadle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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G. (1971). Allergy problems with foot and mouth disease vaccine. M.V.Sc. Thesis. University of Liverpool."},{"key":"S0022172400047082_ref016","doi-asserted-by":"publisher","DOI":"10.1002\/bit.260060204"},{"key":"S0022172400047082_ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0034-5288(18)33546-X","article-title":"Immediate-type hypersensitivity in cattle produced by foot and mouth disease vaccines. Demonstration of reaginic antibody","volume":"19","author":"Beadle","year":"1975","journal-title":"Research in Veterinary Science"},{"key":"S0022172400047082_ref003","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400024232"},{"key":"S0022172400047082_ref013","first-page":"439","article-title":"Sensibilisierungsversuche mit Dexamethason und Carboxymethylcellulose beim Pferd","volume":"114","author":"Straub","year":"1972","journal-title":"Schweizer Archiv Tierheilkunde"},{"key":"S0022172400047082_ref004","volume-title":"European Commission for the Control of Foot and Mouth Disease. Report of the Meeting of the Research Group of the Standing Technical Committee. Brescia, Italy. 1969","author":"Capstick","year":"1970"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400047082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T15:25:22Z","timestamp":1559143522000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400047082\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,8]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,8]]}},"alternative-id":["S0022172400047082"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400047082","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1975,8]]},"assertion":[{"value":"Cambridge University Press 1975","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}