{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T12:17:17Z","timestamp":1648901837402},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T00:00:00Z","timestamp":1242345600000},"content-version":"unspecified","delay-in-days":11975,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1976,8]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Two tests for the estimation of Vi antibody in sera were studied and their validity in the screening of typhoid carriers was assessed. One was a modified Vi haemagglutination test in which Vi-coated glutaraldehyde-fixed erythrocytes were used as the antigen and Vi antibody resistant to treatment with 2-mercaptoethanol was titrated. The other was a fluorescent Vi antibody test in which acetone-fixed bacterial Vi cells were used as the antigen and the total Vi antibody was titrated. In both tests, the antigens used were stable so that standardization of the tests would not be difficult. The modified Vi haemagglutination test was found equally sensitive but more specific in giving less false positives than the conventional Vi haemagglutination test. The fluorescent Vi antibody test was however found superior to both tests not only in giving less false positives but also in detecting more typhoid carriers.<\/jats:p>","DOI":"10.1017\/s002217240005556x","type":"journal-article","created":{"date-parts":[[2009,5,15]],"date-time":"2009-05-15T09:52:05Z","timestamp":1242381125000},"page":"97-104","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":12,"title":["Modified Vi tests in the screening of typhoid carriers"],"prefix":"10.1017","volume":"77","author":[{"given":"P. Y.","family":"Chau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C. H.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,5,15]]},"reference":[{"key":"S002217240005556X_ref010","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400038882"},{"key":"S002217240005556X_ref005","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)40980-3"},{"key":"S002217240005556X_ref006","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5550.472"},{"key":"S002217240005556X_ref001","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.54.9.1507"},{"key":"S002217240005556X_ref009","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1128\/JB.92.4.880-886.1966","article-title":"Agglutinating and precipitating capacity of rabbit anti-Salmonella typhosa \u03b3G and \u03b3M antibodies during prolonged immunization","volume":"92","author":"Pike","year":"1966","journal-title":"Journal of Bacteriology"},{"key":"S002217240005556X_ref002","first-page":"407","article-title":"Study on the production of IgG-, IgA- and IgM-antibodies to somatic antigens of Salmonella typhi in humans","volume":"4","author":"Chernokrvostova","year":"1969","journal-title":"Clinical and Experimental Immunology"},{"key":"S002217240005556X_ref008","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-82-20188"},{"key":"S002217240005556X_ref013","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1128\/AEM.24.4.628-633.1972","article-title":"Isolation of Vi antigen and a simple method for its measurement","volume":"24","author":"Wong","year":"1972","journal-title":"Applied Microbiology"},{"key":"S002217240005556X_ref011","doi-asserted-by":"publisher","DOI":"10.1084\/jem.122.2.385"},{"key":"S002217240005556X_ref012","first-page":"2025","volume-title":"Topley and Wilson's Principles of Bacteriology, Virology and Immunity","volume":"1","author":"Wilson","year":"1975"},{"key":"S002217240005556X_ref003","doi-asserted-by":"crossref","first-page":"750","DOI":"10.5694\/j.1326-5377.1965.tb19225.x","article-title":"Significance of the Vi haemagglutination test","volume":"ii","author":"Cooper","year":"1965","journal-title":"Medical Journal of Australia"},{"key":"S002217240005556X_ref004","first-page":"264","article-title":"Sensitized and stabilized red blood cells coated with Vi antigen as a sensitive tool for the detection of Vi agglutinins","volume":"148","author":"Eskenazy","year":"1974","journal-title":"Zeitschrift f\u00fcr Immunit\u00e4tsforschung"},{"key":"S002217240005556X_ref007","first-page":"111","article-title":"Use of an erythrocytic Vi diagnostic agent to detect chronic typhoid carriers","volume":"42","author":"Kolubaxina","year":"1965","journal-title":"Zhurnal Mikrobiologii, Epidemiologii i Immunobiologii"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002217240005556X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T05:12:29Z","timestamp":1589778749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002217240005556X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1976,8]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1976,8]]}},"alternative-id":["S002217240005556X"],"URL":"https:\/\/doi.org\/10.1017\/s002217240005556x","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1976,8]]},"assertion":[{"value":"Cambridge University Press 1976","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}