{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:29:16Z","timestamp":1759991356195},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T00:00:00Z","timestamp":1255910400000},"content-version":"unspecified","delay-in-days":9515,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"short-container-title":["J. Hyg."],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:p>Records of 171 cases of bacterial meningitis admitted to Nottingham hospitals from January 1974 to June 1980 were reviewed. The distribution of organisms producing meningitis and the factors influencing mortality in different age groups were assessed. <jats:italic>Neisseria meningitidis, Haemophilus infiuenzae<\/jats:italic> and <jats:italic>Streptococcus pneumoniae<\/jats:italic> accounted for 69% of all proven cases. The overall mortality was 26% being lowest in patients with meningococcal meningitis (0%) and highest in those with pneumococcal meningitis (53%). The following factors were associated with a poor prognosis: age more than 40 years, or less than 2 months; state of consciousness on admission; high CSF protein concentration; and a positive blood culture. There was no evidence that antibiotic therapy prior to admission affected prognosis. Although many laboratory findings were altered by prior treatment with antibiotics, this did not prevent the establishment of a diagnosis in the individual patient.<\/jats:p>","DOI":"10.1017\/s0022172400060198","type":"journal-article","created":{"date-parts":[[2009,10,19]],"date-time":"2009-10-19T13:01:37Z","timestamp":1255957297000},"page":"189-201","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Bacterial meningitis in Nottingham"],"prefix":"10.1017","volume":"91","author":[{"given":"P.","family":"Ispahani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2009,10,19]]},"reference":[{"key":"S0022172400060198_ref007","first-page":"953","article-title":"Meningococcal meningitis","volume":"ii","year":"1979","journal-title":"British Medical Journal"},{"key":"S0022172400060198_ref029","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196504082721406"},{"key":"S0022172400060198_ref021","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1976.8.issue-3.12"},{"key":"S0022172400060198_ref011","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92921-4"},{"key":"S0022172400060198_ref005","doi-asserted-by":"publisher","DOI":"10.1017\/S002217240007025X"},{"key":"S0022172400060198_ref012","doi-asserted-by":"publisher","DOI":"10.1136\/adc.52.6.501"},{"key":"S0022172400060198_ref001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91985-1"},{"key":"S0022172400060198_ref003","doi-asserted-by":"publisher","DOI":"10.1016\/S0033-3506(80)80117-X"},{"key":"S0022172400060198_ref020","first-page":"787","article-title":"Intraventricular gentamicin therapy in gram-negative bacillary meningitis of infancy. Report of the Second Neonatal Meningitis Cooperative Study Group","volume":"i","author":"McCracken","year":"1980","journal-title":"Lancet"},{"key":"S0022172400060198_ref023","doi-asserted-by":"publisher","DOI":"10.3109\/inf.1978.10.issue-3.05"},{"key":"S0022172400060198_ref013","doi-asserted-by":"publisher","DOI":"10.1136\/adc.51.8.569"},{"key":"S0022172400060198_ref004","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80479-2"},{"key":"S0022172400060198_ref022","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1935.02760340014006"},{"key":"S0022172400060198_ref019","first-page":"850","article-title":"Pneumococca! meningitis in children","volume":"131","author":"Laxey","year":"1977","journal-title":"American Journal of Diseases in Children"},{"key":"S0022172400060198_ref014","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00000441-197511000-00003","article-title":"Acute bacterial meningitis: an analysis of factors influencing prognosis","volume":"270","author":"Hodoes","year":"1975","journal-title":"American Journal of Medical Sciences"},{"key":"S0022172400060198_ref010","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1981.00510120049006"},{"key":"S0022172400060198_ref017","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1979.03290290032021"},{"key":"S0022172400060198_ref006","first-page":"340","article-title":"Partly treated pyogenic meningitis","volume":"i","year":"1977","journal-title":"British Medical Journal"},{"key":"S0022172400060198_ref031","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1967.00300040001001"},{"key":"S0022172400060198_ref026","first-page":"35","article-title":"Bacterial meningitis. A 15 year review of bacterial meningitis from departments of internal medicine","volume":"24","author":"Romer","year":"1977","journal-title":"Danish Medical Bulletin"},{"key":"S0022172400060198_ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91498-2"},{"key":"S0022172400060198_ref025","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.16.1.13"},{"key":"S0022172400060198_ref009","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/2.5.725"},{"key":"S0022172400060198_ref016","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197512112932401"},{"key":"S0022172400060198_ref028","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/143.2.293"},{"key":"S0022172400060198_ref018","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(81)90240-0"},{"key":"S0022172400060198_ref030","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91933-5"},{"key":"S0022172400060198_ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(62)90024-4"},{"key":"S0022172400060198_ref024","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1962.tb04219.x"},{"key":"S0022172400060198_ref008","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90016-1"},{"key":"S0022172400060198_ref015","doi-asserted-by":"publisher","DOI":"10.1177\/000992287201100406"}],"container-title":["Journal of Hygiene"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022172400060198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T22:23:34Z","timestamp":1558650214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022172400060198\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["S0022172400060198"],"URL":"https:\/\/doi.org\/10.1017\/s0022172400060198","relation":{},"ISSN":["0022-1724"],"issn-type":[{"value":"0022-1724","type":"print"}],"subject":[],"published":{"date-parts":[[1983,10]]},"assertion":[{"value":"Cambridge University Press 1983","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}